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Table 5 Univariate analysis and multivariate analysis of overall survival in 120 gastric cancer patients

From: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients

Variables Univariate analysis Multivariate analysis
Hazard Ratio 95% CI P value Hazard Ratio 95% CI P value
Sex 1.15 0.70–1.89 0.58 1.03 0.60–1.77 0.91
Age 0.93 0.59–1.46 0.75 0.76 0.45–1.29 0.31
Tumor size 0.94 0.47–1.90 0.87 0.77 0.35–1.71 0.52
Differentiation 1.30 0.72–2.37 0.38 1.07 0.54–2.14 0.84
Tumor location 1.09 0.68–1.75 0.71 1.10 0.54–2.14 0.84
Depth of invasion 1.49 0.80–2.76 0.21 1.81 0.76–4.33 0.18
LN metastasis 1.31 0.73–2.34 0.36 1.31 0.62–2.79 0.48
Distant metastasis 0.83 0.26–2.63 0.75 0.66 0.97–4.45 0.67
TNM stage 1.30 0.77–2.19 0.33 0.70 0.30–1.63 0.41
HER2 expression 1.61 0.94–2.74 0.08 5.98 0.97–36.72 0.054
HER3 expression 2.20 1.38–3.52 0.001 1.82 0.93–3.57 0.08
HER2-HER3 co-expression 1.56 0.88–2.75 0.13 6.21 0.95–40.89 0.057
Akt expression 1.79 1.04–3.08 0.04 1.64 0.87–3.12 0.13
p-Akt expression 1.42 0.87–2.27 0.15 0.88 0.46–1.68 0.69
mTOR expression 1.33 0.84–2.11 0.22 1.14 0.64–2.03 0.67
p-mTOR expression 1.88 1.19–2.99 0.01 1.47 0.75–2.87 0.26