From: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients

Variables | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|

Hazard Ratio | 95% CI |
P value
| Hazard Ratio | 95% CI |
P value
| |

Sex | 1.15 | 0.70–1.89 | 0.58 | 1.03 | 0.60–1.77 | 0.91 |

Age | 0.93 | 0.59–1.46 | 0.75 | 0.76 | 0.45–1.29 | 0.31 |

Tumor size | 0.94 | 0.47–1.90 | 0.87 | 0.77 | 0.35–1.71 | 0.52 |

Differentiation | 1.30 | 0.72–2.37 | 0.38 | 1.07 | 0.54–2.14 | 0.84 |

Tumor location | 1.09 | 0.68–1.75 | 0.71 | 1.10 | 0.54–2.14 | 0.84 |

Depth of invasion | 1.49 | 0.80–2.76 | 0.21 | 1.81 | 0.76–4.33 | 0.18 |

LN metastasis | 1.31 | 0.73–2.34 | 0.36 | 1.31 | 0.62–2.79 | 0.48 |

Distant metastasis | 0.83 | 0.26–2.63 | 0.75 | 0.66 | 0.97–4.45 | 0.67 |

TNM stage | 1.30 | 0.77–2.19 | 0.33 | 0.70 | 0.30–1.63 | 0.41 |

HER2 expression | 1.61 | 0.94–2.74 | 0.08 | 5.98 | 0.97–36.72 | 0.054 |

HER3 expression | 2.20 | 1.38–3.52 | 0.001 | 1.82 | 0.93–3.57 | 0.08 |

HER2-HER3 co-expression | 1.56 | 0.88–2.75 | 0.13 | 6.21 | 0.95–40.89 | 0.057 |

Akt expression | 1.79 | 1.04–3.08 | 0.04 | 1.64 | 0.87–3.12 | 0.13 |

p-Akt expression | 1.42 | 0.87–2.27 | 0.15 | 0.88 | 0.46–1.68 | 0.69 |

mTOR expression | 1.33 | 0.84–2.11 | 0.22 | 1.14 | 0.64–2.03 | 0.67 |

p-mTOR expression | 1.88 | 1.19–2.99 | 0.01 | 1.47 | 0.75–2.87 | 0.26 |