Prediction of postoperative inflammatory complications after esophageal cancer surgery based on early changes in the C-reactive protein level in patients who received perioperative steroid therapy and enhanced recovery after surgery care: a retrospective analysis

Table 3 Predictive factors for serious infectious complications

Factors	Number of patients (%)	Univariate			Multivariate
Factors	Number of patients (%)	OR	95% CI	p value	OR	95% CI	p value
Age (years)				0.271
≤66	60 (51.3%)	1.000
>66	57 (48.7%)	1.730	0.651-4.620
Gender				0.246
Female	23 (19.7%)	1.000
Male	94 (80.3%)	2.490	0.534-11.600
Preoperative body mass index (kg/m2)				0.183
≤21	57 (48.7%)	1.000
>21	60 (51.3%)	1.980	0.726-5.380
ASA-PS				0.531
1	17 (14.5%)	1.000
2/3	100 (85.5%)	1.650	0.346-7.840
Preoperative serum albumin (g/dl)				0.900
≥4.1	60 (51.3%)	1.000
<4.1	57 (48.7%)	1.060	0.406-2.790
UICC clinical T factor before neoadjuvant chemotherapy				0.308
cT1-2	41 (35.0%)	1.000
cT3	76 (65.0%)	0.602	0.226-1.600
UICC clinical N factor before neoadjuvant chemotherapy				0.786
cN0	50 (42.7%)	1.000
cN1-2	67 (57.3%)	1.150	0.430-3.050
Lymph node dissection				0.011			0.005
Two-field	95 (81.2%)	1.000			1.000
Three-field	22 (18.8%)	3.950	1.370-11.400		7.950	1.900-33.400
Operation time (min)				0.135
≤400	59 (50.4%)	1.000
>400	58 (49.6%)	2.150	0.788-5.840
Intraoperative blood loss (ml)				0.237
≤420	61 (52.1%)	1.000
>420	56 (47.9%)	1.810	0.678-4.810
CRP on POD4 (mg/dl)				<0.001			<0.001
≤4.0	77 (65.8%)	1.000			1.000
>4.0	40 (34.5%)	12.200	3.710-39.900		18.600	4.610-75.200

SICs Serious infectious complications, CI Confidence interval, OR odds ratio, ASA-PS American Society of Anesthesiologists Physical Status, CRP C-reactive protein; POD, postoperative day, UICC Union for International Cancer Control

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