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Fig. 1 | BMC Cancer

Fig. 1

From: Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin

Fig. 1

The PKCα - FOXC2 - p120-catenin pathway is prognostically relevant in breast cancer patients. a High expression of FOXC2 and low expression of CTNND1 (p120-catenin) in ER− patients correlate with poorer relapse free survival (RFS). b TNBC/Basal-like patients express higher levels of PRKCA (PKCα), FOXC2, and lower levels of CTNND1 compared to patients of other molecular subtypes. Molecular subtypes were determined by PAM50 assay. Gene expression data were computed and analyzed on UCSC Genome Browser (http://genome.ucsc.edu/). c High expression of FOXC2 and low expression of CTNND1 in ER+ patients are associated with a tendency towards poorer RFS. Survival data and significance were analyzed and obtained from PROGgene as previously described [55]

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BMC Cancer

ISSN: 1471-2407

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