Fig. 1

Detected mutational signatures for donor-matched primary/untreated and relapse/treated samples. (Top) Signatures detected in the pre-treatment samples. The first four signatures were extracted from reports of a G. gallus cell line and C. elegans after exposure to chemotherapy, and the rest are COSMIC curated signatures. COSMIC signature numbers are shown in parentheses, and the associated mutagenic process is indicated when known. Signatures not shown were undetected in these samples. (Bottom) Clinical treatments and detected signatures for the mutations unique to the post-treatment samples. Cases where a chemotherapy signature is detected are annotated with a (*) if the patient received the associated drug and a (?) otherwise