Fig. 6
From: CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis
MDA-MB-231.CCR5−/− tumor cells harvested from NSG mice exhibit lower glucose uptake, reduced GLUT-1 expression and lower levels of cellular metabolites than MDA-MB-231.CCR5+/+ tumor cells. MDA-MB-231.CCR5+/+ and MDA-MB-231.CCR5−/− tumors were harvested from recipient NSG mice when they were either just palpable (~20mm3), i.e. tumor onset, or ~700mm3, endpoint. Following 16 h in culture, a glucose uptake, b GLUT-1 expression, and c CCL5 production, were measured. Values are the means ± SEM of technical triplicates. ** p < 0.01 and *** p < 0.001