Fig. 5
From: CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis
MDA-MB-231.CCR5−/− cells transplanted in NSG mice exhibit delayed tumor growth compared with MDA-MB-231.CCR5+/+ cells. MDA-MB-231.CCR5−/− and MDA-MB-231.CCR5+/+ cells were injected into mammary fat pads of NSG mice (n = 12), as described in Methods. Tumor growth was monitored externally using calipers. a Time to palpable tumor onset (~20mm3). Each data point represents a single mouse. b Tumor volume was measured over time to determine tumor growth. Means and SEM are identified as horizontal lines. c Onset tumors were frozen, thin sections prepared and stained with H & E. Arrows show indicated features. d The average number of mitotic figures in each of 5 fields/thin section at 20× magnification are recorded.* p < 0.05