Fig. 2
From: CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis
MMTV-PyMT.CCR5−/− tumor cells transplanted into NSG mice exhibit delayed tumor growth compared with MMTV-PyMT.CCR5+/+ tumor cells. Tumors (100-700 mm3) from MMTV-PyMT.CCR5+/+ and MMTV-PyMT.CCR5−/− mice were harvested and injected into the lower mammary fat pads of NSG recipients (n = 12), as described in Methods. Tumor growth was monitored externally using calipers. a Time to palpable tumor onset (~20mm3) and b tumor endpoint (~700mm3). Each data point represents a single mouse. c Tumor volume was measured over time to determine the rate of tumor growth. Means and SEM are identified as horizontal lines. d Onset tumors were harvested, fixed, thin sections prepared and stained with H & E. Arrows show indicated features. e The average number of mitotic figures in each of 5 fields/thin section at 20× magnification are recorded. * p < 0.05 and *** p < 0.001