Fig. 4

Multi-region microarray profiling from 6 breast tumors. a Bar graph illustrating the number of intra–tumor pieces analysed per breast tumor from 6 breast cancer patients. b PCA score plot of the retrospective validation cohort. Labels show patient IDs. Multiple intra-tumor pieces from the same patient are connected by lines. (Key: LumA = Luminal A (red colour), LumB = Luminal B (blue colour), HER2 = HER2-enriched (green colour), Basal = Basal-like (purple colour). c mRNA expression levels of ER, PR, HER2 and MKI67 across 19 tumor pieces from 6 multi region profiled patients