| |
Chemotherapy (N = 31)
|
Best supportive care (N = 28)
|
p-value
|
|---|
|
Age
|
78.0 [76.5–80.0]
|
80.5 [77.0–84.3]
|
0.118
|
|
Gender (male/female)
|
4 / 27
|
4 / 24
|
1.00
|
|
ECOG Performance Status (2/3/4)
|
18/12/1
|
8/15/5
|
0.0350
|
|
Smoking history
|
30 (96.8%)
|
22 (78.6%)
|
0.0870
|
|
Brinkman Index
|
1100 [780–1550]
|
800 [420–1395]
|
0.113
|
|
Comorbidities
|
|
Emphysema (%)
|
26 (83.9%)
|
20 (71.4%)
|
0.348
|
|
Interstitial pneumonia (%)
|
1 (3.2%)
|
1 (3.6%)
|
1.00
|
|
Diabetes mellitus (%)
|
13 (41.9%)
|
1 (3.6%)
|
0.00100
|
|
Histology (Non-Squamous/Squamous)
|
6 / 25
|
6 / 22
|
1.00
|
|
Staging (IIB/IV)
|
5 / 26
|
2 / 26
|
0.428
|
|
Major diameter of the primary site
|
39.5 [27.5–65.0]
|
52.0 [40.5–74.0]
|
0.0740
|
|
Metastatic organ
|
|
Brain (%)
|
6 (19.4%)
|
4 (14.3%)
|
0.734
|
|
Bone (%)
|
10 (32.3%)
|
6 (21.4%)
|
0.393
|
|
Liver (%)
|
3 (9.7%)
|
3 (10.7%)
|
1.00
|
|
Adrenal gland (%)
|
4 (12.9%)
|
1 (3.6%)
|
0.356
|
|
Laboratory data
|
|
White blood cell count
|
7800 [6450–9700]
|
7700 [6175–11,925]
|
0.802
|
|
Neutrophil count
|
5336 [4502–6684]
|
5988 [4513–8929]
|
0.362
|
|
Lymphocyte count
|
1396 [1148–1721]
|
1086 [848–1432]
|
0.0370
|
|
Hemoglobin
|
12.4 [11.0–14.0]
|
12.0 [11.5–13.2]
|
0.885
|
|
Albumin
|
3.60 [3.20–3.95]
|
3.30 [2.85–3.62]
|
0.0460
|
|
Lactate dehydrogenase
|
214 [188–247]
|
247 [206–277]
|
0.141
|
|
Calcium
|
9.20 [9.00–9.55]
|
9.00 [8.47–9.33]
|
0.093
|
|
C-reactive protein
|
1.81 [0.66–3.92]
|
3.20 [0.57–7.59]
|
0.391
|
- Categorical data are presented as numbers (percentages) whereas continuous data are presented as medians (interquartile ranges). Fisher’s exact test was used to compare categorical data, and the Mann–Whitney U test was used to compare continuous data
- Abbreviations: ECOG Eastern Cooperative Oncology Group
