Table 3 Survival analysis of PFS
From: Clinical significance of PCDH10 promoter methylation in diffuse large B-cell lymphoma
PFS | ||||
|---|---|---|---|---|
HR_U(95%CI) | p value | HR_M(95%CI) | p value | |
Age at diagnosis | ||||
<60y | 1.000 | |||
≥ 60y | 1.557(0.731–3.314) | 0.251 | ||
Sex | ||||
Male | 1.000 | |||
Female | 1.067(0.501–2.272) | 0.867 | ||
Primary site | ||||
Extranodal | 1.000 | |||
Nodala | 2.422(0.976-6.007) | 0.056 | ||
IPI risk category | ||||
Low | 1.000 | 1.000 | ||
Low-intermediate | 2.456(0.825–7.313) | 0.107 | 2.474(0.829–7.389) | 0.105 |
High-intermediate | 3.895(1.360–11.151) | 0.011 | 3.687(1.259–10.795) | 0.017 |
High | 9.202(3.156–26.832) | <0.001 | 8.680(2.874–26.215) | <0.001 |
Treatment | ||||
RCHOP | 1.000 | 1.000 | ||
Resection & RCHOP | 0.090(0.012–0.668) | 0.018 | 0.119(0.016–0.903) | 0.040 |
Hans Algorithm | ||||
GCB | 1.000 | |||
Non-GCB | 1.410(0.617–3.222) | 0.415 | ||
PCDH10 Methylation | ||||
No | 1.000 | 1.000 | ||
Yes | 2.687(1.173–6.156) | 0.019 | 2.977(1.245–7.119) | 0.014 |
MYC FISH Breakapart | ||||
No | 1.000 | |||
Yes | 0.716(0.097–5.279) | 0.743 | ||