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Table 3 Survival analysis of PFS

From: Clinical significance of PCDH10 promoter methylation in diffuse large B-cell lymphoma

  PFS
HR_U(95%CI) p value HR_M(95%CI) p value
Age at diagnosis
 <60y 1.000    
  ≥ 60y 1.557(0.731–3.314) 0.251   
Sex
 Male 1.000    
 Female 1.067(0.501–2.272) 0.867   
Primary site
 Extranodal 1.000    
 Nodala 2.422(0.976-6.007) 0.056   
IPI risk category
 Low 1.000   1.000  
 Low-intermediate 2.456(0.825–7.313) 0.107 2.474(0.829–7.389) 0.105
 High-intermediate 3.895(1.360–11.151) 0.011 3.687(1.259–10.795) 0.017
 High 9.202(3.156–26.832) <0.001 8.680(2.874–26.215) <0.001
Treatment
 RCHOP 1.000   1.000  
 Resection & RCHOP 0.090(0.012–0.668) 0.018 0.119(0.016–0.903) 0.040
Hans Algorithm
 GCB 1.000    
 Non-GCB 1.410(0.617–3.222) 0.415   
PCDH10 Methylation
 No 1.000   1.000  
 Yes 2.687(1.173–6.156) 0.019 2.977(1.245–7.119) 0.014
MYC FISH Breakapart
 No 1.000    
 Yes 0.716(0.097–5.279) 0.743   
  1. HR_U hazard ratio by univariate analysis, HR_M hazard ratio by multivariate analysis
  2. aDLBCL arising in spleen was considered as primary nodal lymphoma [20]