Table 6 Chou Talalay Drug Synergism (Combination Index)

MCF7 (ER+)

CI (mean ± SD)

 4 μM SKI-II + 0.4 μM OSI-906 – MTT Assay

0.49 ± 0.40 (n = 3)

 4 μM SKI-II + 0.4 μM OSI-906 – Clonogenic Assay

0.38 ± 0.28 (n = 6)

T47D (ER+)

CI (mean ± SD)

 4 μM SKI-II + 0.4 μM OSI-906 – Clonogenic Assay

0.21 ± 0.05 (n = 3)

HCC1806 (ER-)

CI (mean ± SD)

 4 μM SKI-II + 6.4 μM OSI-906 – Clonogenic Assay

0.01 ± 0.01 (n = 2)