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Table 6 Chou Talalay Drug Synergism (Combination Index)

From: Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

MCF7 (ER+) CI (mean ± SD)
 4 μM SKI-II + 0.4 μM OSI-906 – MTT Assay 0.49 ± 0.40 (n = 3)
 4 μM SKI-II + 0.4 μM OSI-906 – Clonogenic Assay 0.38 ± 0.28 (n = 6)
T47D (ER+) CI (mean ± SD)
 4 μM SKI-II + 0.4 μM OSI-906 – Clonogenic Assay 0.21 ± 0.05 (n = 3)
HCC1806 (ER-) CI (mean ± SD)
 4 μM SKI-II + 6.4 μM OSI-906 – Clonogenic Assay 0.01 ± 0.01 (n = 2)
  1. Abbreviation: CI Combination Index