Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

Table 3 Summary of Kaplan-Meier Analyses

Prognostic Marker	Log-rank p-value	Total number	Events
Non-Stratified
IGF1R	0.018*	233	19
SphK1	0.427	233	19
IGF1R/SphK1	0.028*	232	19
pIGF1R	0.303	232	19
pIGF1R/SphK1	0.118	232	19
ER-positive
IGF1R	0.048*	165	11
SphK1	0.250	165	11
IGF1R/SphK1	0.051	165	11
ER-negative
IGF1R	0.445	68	8
SphK1	0.675	68	8
IGF1R/SphK1	0.582	68	8
Anti-Endocrine Therapy (AET)
AET-positive vs. AET-negative	0.006*	190	17
AET-positive
IGF1R	0.028*	190	17
SphK1	0.101	190	17
IGF1R/SphK1	0.034*	190	17
HER2-negative
IGF1R	0.074	143	4
SphK1	0.052	143	4
pIGF1R	0.273	142	4
HER2-positive
IGF1R	0.195	86	14
SphK1	0.062	86	14
pIGF1R	0.858	86	14
PR-negative
IGF1R	0.290	81	10
SphK1	0.296	81	10
pIGF1R	0.410	81	10
PR-positive
IGF1R	0.101	147	8
SphK1	0.293	147	8
pIGF1R	0.588	146	8

ISSN: 1471-2407