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Table 3 Summary of Kaplan-Meier Analyses

From: Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

Prognostic Marker Log-rank p-value Total number Events
Non-Stratified
 IGF1R 0.018* 233 19
 SphK1 0.427 233 19
 IGF1R/SphK1 0.028* 232 19
 pIGF1R 0.303 232 19
 pIGF1R/SphK1 0.118 232 19
ER-positive
 IGF1R 0.048* 165 11
 SphK1 0.250 165 11
 IGF1R/SphK1 0.051 165 11
ER-negative
 IGF1R 0.445 68 8
 SphK1 0.675 68 8
 IGF1R/SphK1 0.582 68 8
Anti-Endocrine Therapy (AET)
 AET-positive vs. AET-negative 0.006* 190 17
AET-positive
 IGF1R 0.028* 190 17
 SphK1 0.101 190 17
 IGF1R/SphK1 0.034* 190 17
HER2-negative
 IGF1R 0.074 143 4
 SphK1 0.052 143 4
 pIGF1R 0.273 142 4
HER2-positive
 IGF1R 0.195 86 14
 SphK1 0.062 86 14
 pIGF1R 0.858 86 14
PR-negative
 IGF1R 0.290 81 10
 SphK1 0.296 81 10
 pIGF1R 0.410 81 10
PR-positive
 IGF1R 0.101 147 8
 SphK1 0.293 147 8
 pIGF1R 0.588 146 8
  1. High vs. low prognostic marker expression *p-value significant; ≤0.05