Table 3 Association of demographic and clinicopathologic profiles with IHC defined subtypes of BC in both Eritrean and Sudanese women
Demographic and tumour characteristics | IHC defined breast cancer subtypes | P value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Luminal A | Luminal B | HER2 enriched | TNBC | |||||||
n | % | n | % | n | % | n | % | |||
Age in years | ≤50 | 131 | 37.1% | 35 | 9.9% | 53 | 15.0% | 134 | 38.0% | 0.015 |
>50 | 65 | 32.3% | 35 | 17.4% | 40 | 19.9% | 61 | 30.3% | ||
Nationality | Sudanese | 153 | 35.0% | 56 | 12.8% | 73 | 16.7% | 155 | 35.5% | 0.924 |
Eritrean | 42 | 36.2% | 14 | 12.1% | 20 | 17.2% | 40 | 34.5% | ||
Histologic type | aIDCNST | 159 | 33.3% | 65 | 13.6% | 85 | 17.8% | 168 | 35.2% | 0.056 |
bILC | 16 | 61.5% | 1 | 3.8% | 5 | 19.2% | 4 | 15.4% | ||
Medullary | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 13 | 100.0% | ||
Mucinous | 16 | 94.1% | 1 | 5.9% | 0 | 0.0% | 0 | 0.0% | ||
Papillary | 1 | 6.7% | 3 | 20.0% | 2 | 13.3% | 9 | 60.0% | ||
Cribriform | 4 | 100.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||
Pathologic tumour size | pT1 | 45 | 47.9% | 14 | 14.9% | 10 | 10.6% | 25 | 26.6% | .041 |
pT2 | 74 | 31.1% | 35 | 14.7% | 48 | 20.2% | 81 | 34.0% | ||
pT3 | 43 | 31.2% | 13 | 9.4% | 23 | 16.7% | 59 | 42.8% | ||
pT4 | 27 | 40.3% | 7 | 10.4% | 9 | 13.4% | 24 | 35.8% | ||
Lymph Node involvement | pN0 | 102 | 42.7% | 31 | 13.0% | 34 | 14.2% | 72 | 30.1% | 0.58 |
pN1 | 22 | 27.5% | 10 | 12.5% | 19 | 23.8% | 29 | 36.3% | ||
pN2 | 25 | 29.8% | 15 | 17.9% | 14 | 16.7% | 30 | 35.7% | ||
pN3 | 12 | 21.4% | 8 | 14.3% | 7 | 12.5% | 29 | 51.8% | ||
Nottingham Grade | GI | 19 | 67.9% | 3 | 10.7% | 4 | 14.3% | 2 | 7.1% | 0.000 |
GII | 123 | 45.7% | 25 | 9.3% | 36 | 13.4% | 85 | 31.6% | ||
GIII | 54 | 21.0% | 42 | 16.3% | 53 | 20.6% | 108 | 42.0% | ||