Table 1 Baseline patient characteristics
Variables | All N = 30 | Cachexia N = 19 | Non-cachexia N = 11 | p-value* |
|---|---|---|---|---|
Age, median (range) | 74 (70–82) | 76 (70–82) | 73 (70–80) | <0.05 |
Gender (Women:Men) | 11:19 | 8:11 | 3:8 | NS |
ECOG-PS, n (%) | ||||
 0 | 11 (36.7) | 5 (26.3) | 6 (54.6) | NS |
 1 | 18 (60.0) | 13 (68.4) | 5 (45.5) |  |
 2 | 1 (3.3) | 1 (5.3) | 0 (0.0) |  |
Stage, n (%) | ||||
 IIIA or IIIB | 1 (3.3) | 1 (5.3) | 0 (0.0) | NS |
 IV or postoperative recurrence | 29 (96.7) | 18 (94.7) | 11 (100.0) |  |
Tumor Histology, n (%) | ||||
 Adenocarcinoma | 21 (70.0) | 13 (68.4) | 8 (72.7) | NS |
 Other non-small-cell lung cancer | 9 (30.0) | 6 (31.6) | 3 (27.3) |  |
EGFR gene | ||||
 Mutant | 7 (23.3) | 5 (26.3) | 2 (18.2) | NS |
 Wild type or unknown | 23 (76.7) | 14 (73.7) | 9 (81.8) |  |
Treatment, n (%) | ||||
 Cytotoxic regimen | 24 (80.0) | 15 (79.0) | 9 (81.8) | NS |
 Targeted regimen | 6 (20.0) | 4 (21.0) | 2 (18.2) |  |
Nutrition | ||||
 BMI (kg/m2) | 21.1 ± 3.4 | 20.4 ± 2.8 | 22.2 ± 1.2 | NS |
 % weight change in prior 6 months (%, mean ± SD) | −6.0 ± 6.4 | −9.4 ± 5.5 | −0.1 ± 2.2 | <0.05 |
 Malnutrition or at risk of malnutritiona, n (%) | 17 (56.7) | 14 (73.7) | 3 (27.3) | <0.05 |
 Skeletal muscle depletionb | 20 (66.7) | 13 (68.4) | 7 (63.6) | NS |
 Lumbar skeletal muscle index (cm2/m2) | ||||
  Women | 35.4 ± 4.1 | 34.1 ± 3.9 | 39.0 ± 2.2 | NS |
  Men | 44.5 ± 7.6 | 42.3 ± 6.1 | 47.6 ± 8.8 | NS |
Physical capacity | ||||
 Incremental shuttle walking distance (m) | ||||
  Women | 304.5 ± 99.2 | 338.8 ± 90.5 | 213.3 ± 58.6 | NS |
  Men | 338.4 ± 143.0 | 283.6 ± 146.5 | 413.8 ± 103.5 | <0.05 |
 Hand-grip-strength in dominant side (kg) | ||||
  Women | 21.7 ± 4.1 | 22.4 ± 4.5 | 20.0 ± 2.7 | NS |
  Men | 33.9 ± 7.1 | 29.5 ± 4.3 | 39.3 ± 6.0 | <0.05 |