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Table 1 Baseline patient characteristics

From: Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study

Variables All N = 30 Cachexia N = 19 Non-cachexia N = 11 p-value*
Age, median (range) 74 (70–82) 76 (70–82) 73 (70–80) <0.05
Gender (Women:Men) 11:19 8:11 3:8 NS
ECOG-PS, n (%)
 0 11 (36.7) 5 (26.3) 6 (54.6) NS
 1 18 (60.0) 13 (68.4) 5 (45.5)  
 2 1 (3.3) 1 (5.3) 0 (0.0)  
Stage, n (%)
 IIIA or IIIB 1 (3.3) 1 (5.3) 0 (0.0) NS
 IV or postoperative recurrence 29 (96.7) 18 (94.7) 11 (100.0)  
Tumor Histology, n (%)
 Adenocarcinoma 21 (70.0) 13 (68.4) 8 (72.7) NS
 Other non-small-cell lung cancer 9 (30.0) 6 (31.6) 3 (27.3)  
EGFR gene
 Mutant 7 (23.3) 5 (26.3) 2 (18.2) NS
 Wild type or unknown 23 (76.7) 14 (73.7) 9 (81.8)  
Treatment, n (%)
 Cytotoxic regimen 24 (80.0) 15 (79.0) 9 (81.8) NS
 Targeted regimen 6 (20.0) 4 (21.0) 2 (18.2)  
Nutrition
 BMI (kg/m2) 21.1 ± 3.4 20.4 ± 2.8 22.2 ± 1.2 NS
 % weight change in prior 6 months (%, mean ± SD) −6.0 ± 6.4 −9.4 ± 5.5 −0.1 ± 2.2 <0.05
 Malnutrition or at risk of malnutritiona, n (%) 17 (56.7) 14 (73.7) 3 (27.3) <0.05
 Skeletal muscle depletionb 20 (66.7) 13 (68.4) 7 (63.6) NS
 Lumbar skeletal muscle index (cm2/m2)
  Women 35.4 ± 4.1 34.1 ± 3.9 39.0 ± 2.2 NS
  Men 44.5 ± 7.6 42.3 ± 6.1 47.6 ± 8.8 NS
Physical capacity
 Incremental shuttle walking distance (m)
  Women 304.5 ± 99.2 338.8 ± 90.5 213.3 ± 58.6 NS
  Men 338.4 ± 143.0 283.6 ± 146.5 413.8 ± 103.5 <0.05
 Hand-grip-strength in dominant side (kg)
  Women 21.7 ± 4.1 22.4 ± 4.5 20.0 ± 2.7 NS
  Men 33.9 ± 7.1 29.5 ± 4.3 39.3 ± 6.0 <0.05
  1. ECOG-PS Eastern cooperative oncology group performance status, EGFR epidermal growth factor receptor, BMI body-mass-index, NS not significant, SD standard deviation
  2. * Significant difference (P < 0.05) tested by Chi-square test, Fisher exact test, or Wilcoxon test
  3. aMalnutrition or at risk of malnutrition was defined based on the full version of Mini nutritional assessment score < 17 points. bskeletal muscle depletion was defined as lumbar skeletal muscle mass index of <43.0 cm2/m2 for men with a BMI <25.0 kg/m2, <53.0 cm2/m2 for men with a BMI ≥25.0, and <41.0 cm2/m2 in women