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Table 3 Sensitivity and specificity between HPV DNA detection by PCR (“positive result defined as disease for statistical testing”) and p16 by IHC

From: Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh

Point estimate   Confidence limits (95% CI)
Types Value Lower, upper
Sensitivity 72.22% 54.81% to 85.80%
Specificity 98.55% 94.86% to 99.82%
Positive Likelihood Ratio 49.83 12.40 to 200.21
Negative Likelihood Ratio 0.28 0.17 to 0.48
“Disease” prevalence 20.69% (a) 14.93% to 27.47%
Positive Predictive Value 92.86% (a) 76.50% to 99.12%
Negative Predictive Value 93.15% (a) 87.76% to 96.67%
  1. aDoes not reflect real prevalence of the “disease”