Table 1 Demographic and clinical characteristics of patients
From: Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh
Characteristics | All patients (n = 174) (%) | HPV DNA + ve (n = 36) (%) | HPV DNA-ve (n = 138)(%) | X2 (Chi-square) | p-value |
|---|---|---|---|---|---|
Mean Age | 56.6 | 54.2 | 57.2 | Â | 0.143 |
Age groups (years) | |||||
 20–59 | 94 (54.1) | 26 (72.2) | 68 (49.3) | 6.053* | 0.014 |
 60 and above | 80 (45.9) | 10 (27.8) | 70 (50.7) |  |  |
Gender | |||||
 Male | 138 (79.3) | 30 (83.3) | 108 (78.3) | 0.448 | 0.503 |
 Female | 36 (20.7) | 6 (16.7) | 30 (21.7) |  |  |
Primary Tumour sites | |||||
 Oral Cavity (C02-C06) | 55 (31.6) | 11 (30.6) | 44 (31.9) | 8.412* | 0.038 |
 Oropharynx (C01, C09 & C10) | 35 (20.1) | 13 (36.1) | 22 (15.9) |  |  |
 Larynx (C32) | 64 (36.8) | 8 (22.2) | 56 (40.6) |  |  |
 Hypopharynx (C13) | 20 (11.5) | 4 (11.1) | 16 (11.6) |  |  |
Histopathological Grading | |||||
 Well differentiated | 48 (27.6) | 4 (11.1) | 44 (31.9) | 8.947* | 0.011 |
 Moderately differentiated | 92 (52.9) | 20 (55.6) | 72 (52.2) |  |  |
 Poorly differentiated | 34 (19.5) | 12 (33.3) | 22 (15.9) |  |  |
Immunohistochemistry (IHC) Analysis | |||||
p16 expression | |||||
 Positive | 28 (16.1) | 26 (72.2) | 2 (1.4) | 105.914* | 0.0001 |
 Negative | 146 (83.9) | 10 (27.8) | 136 (98.6) |  |  |
p53 expression | |||||
 Positive | 86 (49.4) | 23 (63.9) | 63 (45.7) | 3.799 | 0.051 |
 Negative | 88 (51.6) | 13 (36.1) | 75 (54.3) |  |  |
Cyclin D1 expression | |||||
 Positive | 62 (35.6) | 13 (36.1) | 49 (35.5) | 0.05 | 0.946 |
 Negative | 112 (64.4) | 23 (63.9) | 89 (64.5) |  |  |
pRb expression | |||||
 Positive | 66 (37.9) | 15 (41.7) | 51 (37.0) | 0.269 | 0.604 |
 Negative | 108 (62.1) | 21 (58.3) | 87 (63.0) |  |  |