Variable [Reference] | India | Nicaragua | Uganda |
---|---|---|---|
Population coverage of screening program | 100% | 100% | 100% |
Loss to follow-up per visitb | 10-70% | 10-70% | 10-70% |
Proportion of eligible women receiving immediate cryotherapy following positive careHPV resultb | 100% | 100% | 100% |
careHPV (cervical specimen) sensitivity/specificity for CIN2+ [15] | 90% / 95% | 78% / 89% | 89% / 82% |
Test sensitivity/specificity for CIN1+, colposcopyc | 50% / 96% | 95% / 68% | 95% / 51% |
Eligibility for cryotherapy [22] | |||
 No lesion or CIN1 | 100% | 100% | 100% |
 CIN2 | 85% | 85% | 85% |
 CIN3 | 75% | 75% | 75% |
 Cancer | 10% | 10% | 10% |
92% | 92% | 92% | |
Effectiveness of cryotherapy/LEEP following colposcopy [22, 31] | 96% | 96% | 96% |
Direct medical costs by procedure [14, 15]d | |||
  careHPV (cervical specimen)e | 9.24 | 15.61 | 8.78 |
 Colposcopyf | 9.86 | 15.25 | 7.08 |
 Colposcopy and biopsyf | 30.06 | 39.48 | 32.90 |
 Cryotherapy | 38.13 | 33.04 | 13.49 |
 LEEP | NA | 133.64 | 139.54 |
 Cytology (follow-up post-treatment)g | 15.15 | 13.71 | 12.25 |
Direct non-medical costsd | |||
0.08 | 0.69 | 4.46 | |
 Transportation (round-trip, secondary facility) [22, 33, 34] | 15.29 | 2.75 | 10.87 |
 Women’s time (per hour) [35] | 1.14 | 1.41 | 0.68 |
Treatment of local cancer (FIGO stages 1a-2a)[22, 33, 34]d,h | 1821 | 3322 | 888 |
Treatment of regional/distant cancer (FIGO stages ≥2b)[22, 33, 34]d,h | 2652 | 4268 | 1176 |