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Table 2 The number of ESR1 mutations in primary and metastatic tumors from breast cancer patients

From: Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients

Samples N ESR1 mutations Patients with ESR1 mutation Rate of ESR1 mutation
E380Q Y537S Y537N Y537C D538G
Primary 9 0 0 0 0 0 0 0
Metastasis
 Single site 24 0 2 2 2 3 6a 25% (6/24)
 Multiple sites 33 2 3 2 2 1 6b 18.2% (6/33)
  1. aTwo patients had polyclonal ESR1 mutations, Y537S/Y537N/D538G and Y537N/D538G
  2. bThree patients had polyclonal ESR1 mutations, Y537S/Y537N/D538G, Y537S/Y537C, and Y537S/E380Q