Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients

BMC Cancer

Table 2 The number of ESR1 mutations in primary and metastatic tumors from breast cancer patients

Samples	N	ESR1 mutations					Patients with ESR1 mutation	Rate of ESR1 mutation
Samples	N	E380Q	Y537S	Y537N	Y537C	D538G	Patients with ESR1 mutation	Rate of ESR1 mutation
Primary	9	0	0	0	0	0	0	0
Metastasis
Single site	24	0	2	2	2	3	6^a	25% (6/24)
Multiple sites	33	2	3	2	2	1	6^b	18.2% (6/33)

^aTwo patients had polyclonal ESR1 mutations, Y537S/Y537N/D538G and Y537N/D538G
^bThree patients had polyclonal ESR1 mutations, Y537S/Y537N/D538G, Y537S/Y537C, and Y537S/E380Q

ISSN: 1471-2407