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Fig. 1 | BMC Cancer

Fig. 1

From: Does anthracycline-based chemotherapy in pregnant women with cancer offer safe cardiac and neurodevelopmental outcomes for the developing fetus?

Fig. 1

The mechanism underlying anthracycline-induced myocyte toxicity. DOX: doxorubicin; MT-CK: mitochondrial creatine kinase; Fe2+: iron; ROS: reactive oxygen species; Ca2+: calcium; TOPII: topoisomerase II; trans reg protein: transcriptional regulatory protein. Outside the cell DOX forms iron anthracycline complexes inducing membrane lipid peroxidation. After entering into the cell, DOX by interacting with the topoisomerase-II-beta enzyme, impairs DNA transcription, sarcoplasmic reticulum and muscle proteins. ROS production interacts with cellular iron metabolism causing mitochondrial iron accumulation and toxicity to mitochondrial functioning

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BMC Cancer

ISSN: 1471-2407

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