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Table 2 Cox proportional hazards analysis of overall survival and cancer-specific survival

From: The risk and survival outcome of subsequent primary colorectal cancer after the first primary colorectal cancer: cases from 1973 to 2012

Variable

Overall survival

Cancer-specific survival

 

HR

95% CI

P

HR

95% CI

 

P

Location

   

0.076

   

0.054

 RCC

Referent

   

Referent

   

 LCC

0.94

0.89

0.99

0.028

1.01

0.93

1.10

0.811

 Rectum

0.99

0.91

1.07

0.741

1.15

1.02

1.29

0.022

Age at diagnosis (year)

   

<0.0001

   

<0.0001

  ≤ 50

Referent

   

Referent

   

 51–60

1.70

1.50

1.92

<0.0001

1.27

1.07

1.51

0.007

 61–70

2.35

2.08

2.63

<0.0001

1.35

1.15

1.58

<0.0001

 71–80

3.91

3.46

4.40

<0.0001

1.97

1.68

2.32

<0.0001

  ≥ 81

7.18

6.26

8.22

<0.0001

3.23

2.68

3.91

<0.0001

Stage

   

<0.0001

   

<0.0001

 Localized

Referent

   

Referent

   

 Regional

1.16

1.11

1.23

<0.0001

1.50

1.38

1.63

<0.0001

 Distant

2.17

1.90

2.47

<0.0001

3.72

3.15

4.39

<0.0001

 Unknown

1.21

1.04

1.40

0.014

1.48

1.19

1.85

0.001

Grade

   

0.949

   

0.491

 Grade I

Referent

   

Referent

   

 Grade II

1.01

0.93

1.09

0.853

1.07

0.95

1.22

0.258

 Grade III

1.02

0.93

1.12

0.700

1.12

0.96

1.30

0.148

 Unknown

0.98

0.98

1.07

0.673

1.10

0.95

1.27

0.198

Race

   

<0.0001

   

<0.0001

 White

Referent

   

Referent

   

 Black

1.24

1.13

1.36

<0.0001

1.31

1.14

1.51

<0.0001

 Others

0.94

0.85

1.04

0.223

0.84

1.80

0.99

0.038

Gender

   

<0.0001

   

<0.0001

 Male

Referent

   

Referent

   

 Female

0.74

0.70

0.78

<0.0001

0.83

0.77

0.90

<0.0001

Year of diagnosis

   

<0.0001

   

<0.0001

 1973–1985

Referent

   

Referent

   

 1986–1995

1.27

1.20

1.36

<0.0001

1.24

1.13

1.36

<0.0001

 1996–2005

2.07

2.91

2.51

<0.0001

2.03

1.80

2.28

<0.0001

  1. Abbreviations: HR Hazard ratio, CI confidence interval