|
Variable
|
Overall survival
|
Cancer-specific survival
|
|---|
| |
HR
|
95% CI
|
P
|
HR
|
95% CI
| |
P
|
|---|
|
Location
| | | |
0.076
| | | |
0.054
|
|
RCC
|
Referent
| | | |
Referent
| | | |
|
LCC
|
0.94
|
0.89
|
0.99
|
0.028
|
1.01
|
0.93
|
1.10
|
0.811
|
|
Rectum
|
0.99
|
0.91
|
1.07
|
0.741
|
1.15
|
1.02
|
1.29
|
0.022
|
|
Age at diagnosis (year)
| | | |
<0.0001
| | | |
<0.0001
|
|
≤ 50
|
Referent
| | | |
Referent
| | | |
|
51–60
|
1.70
|
1.50
|
1.92
|
<0.0001
|
1.27
|
1.07
|
1.51
|
0.007
|
|
61–70
|
2.35
|
2.08
|
2.63
|
<0.0001
|
1.35
|
1.15
|
1.58
|
<0.0001
|
|
71–80
|
3.91
|
3.46
|
4.40
|
<0.0001
|
1.97
|
1.68
|
2.32
|
<0.0001
|
|
≥ 81
|
7.18
|
6.26
|
8.22
|
<0.0001
|
3.23
|
2.68
|
3.91
|
<0.0001
|
|
Stage
| | | |
<0.0001
| | | |
<0.0001
|
|
Localized
|
Referent
| | | |
Referent
| | | |
|
Regional
|
1.16
|
1.11
|
1.23
|
<0.0001
|
1.50
|
1.38
|
1.63
|
<0.0001
|
|
Distant
|
2.17
|
1.90
|
2.47
|
<0.0001
|
3.72
|
3.15
|
4.39
|
<0.0001
|
|
Unknown
|
1.21
|
1.04
|
1.40
|
0.014
|
1.48
|
1.19
|
1.85
|
0.001
|
|
Grade
| | | |
0.949
| | | |
0.491
|
|
Grade I
|
Referent
| | | |
Referent
| | | |
|
Grade II
|
1.01
|
0.93
|
1.09
|
0.853
|
1.07
|
0.95
|
1.22
|
0.258
|
|
Grade III
|
1.02
|
0.93
|
1.12
|
0.700
|
1.12
|
0.96
|
1.30
|
0.148
|
|
Unknown
|
0.98
|
0.98
|
1.07
|
0.673
|
1.10
|
0.95
|
1.27
|
0.198
|
|
Race
| | | |
<0.0001
| | | |
<0.0001
|
|
White
|
Referent
| | | |
Referent
| | | |
|
Black
|
1.24
|
1.13
|
1.36
|
<0.0001
|
1.31
|
1.14
|
1.51
|
<0.0001
|
|
Others
|
0.94
|
0.85
|
1.04
|
0.223
|
0.84
|
1.80
|
0.99
|
0.038
|
|
Gender
| | | |
<0.0001
| | | |
<0.0001
|
|
Male
|
Referent
| | | |
Referent
| | | |
|
Female
|
0.74
|
0.70
|
0.78
|
<0.0001
|
0.83
|
0.77
|
0.90
|
<0.0001
|
|
Year of diagnosis
| | | |
<0.0001
| | | |
<0.0001
|
|
1973–1985
|
Referent
| | | |
Referent
| | | |
|
1986–1995
|
1.27
|
1.20
|
1.36
|
<0.0001
|
1.24
|
1.13
|
1.36
|
<0.0001
|
|
1996–2005
|
2.07
|
2.91
|
2.51
|
<0.0001
|
2.03
|
1.80
|
2.28
|
<0.0001
|
-
Abbreviations: HR Hazard ratio, CI confidence interval
