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Table 2 Cox proportional hazards analysis of overall survival and cancer-specific survival

From: The risk and survival outcome of subsequent primary colorectal cancer after the first primary colorectal cancer: cases from 1973 to 2012

Variable Overall survival Cancer-specific survival
  HR 95% CI P HR 95% CI   P
Location     0.076     0.054
 RCC Referent     Referent    
 LCC 0.94 0.89 0.99 0.028 1.01 0.93 1.10 0.811
 Rectum 0.99 0.91 1.07 0.741 1.15 1.02 1.29 0.022
Age at diagnosis (year)     <0.0001     <0.0001
  ≤ 50 Referent     Referent    
 51–60 1.70 1.50 1.92 <0.0001 1.27 1.07 1.51 0.007
 61–70 2.35 2.08 2.63 <0.0001 1.35 1.15 1.58 <0.0001
 71–80 3.91 3.46 4.40 <0.0001 1.97 1.68 2.32 <0.0001
  ≥ 81 7.18 6.26 8.22 <0.0001 3.23 2.68 3.91 <0.0001
Stage     <0.0001     <0.0001
 Localized Referent     Referent    
 Regional 1.16 1.11 1.23 <0.0001 1.50 1.38 1.63 <0.0001
 Distant 2.17 1.90 2.47 <0.0001 3.72 3.15 4.39 <0.0001
 Unknown 1.21 1.04 1.40 0.014 1.48 1.19 1.85 0.001
Grade     0.949     0.491
 Grade I Referent     Referent    
 Grade II 1.01 0.93 1.09 0.853 1.07 0.95 1.22 0.258
 Grade III 1.02 0.93 1.12 0.700 1.12 0.96 1.30 0.148
 Unknown 0.98 0.98 1.07 0.673 1.10 0.95 1.27 0.198
Race     <0.0001     <0.0001
 White Referent     Referent    
 Black 1.24 1.13 1.36 <0.0001 1.31 1.14 1.51 <0.0001
 Others 0.94 0.85 1.04 0.223 0.84 1.80 0.99 0.038
Gender     <0.0001     <0.0001
 Male Referent     Referent    
 Female 0.74 0.70 0.78 <0.0001 0.83 0.77 0.90 <0.0001
Year of diagnosis     <0.0001     <0.0001
 1973–1985 Referent     Referent    
 1986–1995 1.27 1.20 1.36 <0.0001 1.24 1.13 1.36 <0.0001
 1996–2005 2.07 2.91 2.51 <0.0001 2.03 1.80 2.28 <0.0001
  1. Abbreviations: HR Hazard ratio, CI confidence interval