Table 4 Common microRNAs deregulated in canine mammary cancer and human breast cancer [30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45]
microRNA | Canine mammary cancer | Human breast cancer | Target genes | Targets’ function |
|---|---|---|---|---|
miR-10b | down-regulated | down-regulated | BUB1, PLK1, CCNA2 | cell cycle regulation |
miR-15a | down-regulated | down-regulated | CCNE1 | cell cycle regulation |
miR-19a | down-regulated | down-regulated | Fra-1 proto-oncogene | inducing macrophage polarization |
miR-26b | down-regulated | down-regulated | SLC7A11 | apoptosis |
miR-29a | down-regulated | up-regulated | Col4a2, Spry1, Timp3 | antiangiogenic |
miR-30a | down-regulated | down-regulated | MTDH | angiogenesis |
miR-30c | down-regulated | down-regulated | KRAS | signalling |
miR-125a | down-regulated | down-regulated | HER2, HER3 | epidermal growth factor receptors |
miR-125b | down-regulated | down-regulated | HER2, HER3 | epidermal growth factor receptors |
miR-148a | down-regulated | down-regulated | ERBB3 | growth factor |
miR-148b | down-regulated | down-regulated | ITGA5, ROCK1, PIK3CA, NRAS, CSF1 | Â |
miR-181a | down-regulated | up-regulated | ATM | stress-sensor kinase |
miR-195 | down-regulated | down-regulated | CCNE1 | cyclin |
miR-196a | down-regulated | up-regulated | ANXA1 | apoptosis |
miR-320 | down-regulated | down-regulated | TRPC5, NFATC3 | Â |
miR-374a | down-regulated | up-regulated | WIF1, PTEN, WNT5A | negative regulators of the Wnt/β-catenin signalling cascade |
miR-494 | up-regulated | up-regulated | PTEN | negative regulator of the Akt/PKB signalling pathway |