Skip to main content

Advertisement

Table 4 Common microRNAs deregulated in canine mammary cancer and human breast cancer [30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45]

From: MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours

microRNA Canine mammary cancer Human breast cancer Target genes Targets’ function
miR-10b down-regulated down-regulated BUB1, PLK1, CCNA2 cell cycle regulation
miR-15a down-regulated down-regulated CCNE1 cell cycle regulation
miR-19a down-regulated down-regulated Fra-1 proto-oncogene inducing macrophage polarization
miR-26b down-regulated down-regulated SLC7A11 apoptosis
miR-29a down-regulated up-regulated Col4a2, Spry1, Timp3 antiangiogenic
miR-30a down-regulated down-regulated MTDH angiogenesis
miR-30c down-regulated down-regulated KRAS signalling
miR-125a down-regulated down-regulated HER2, HER3 epidermal growth factor receptors
miR-125b down-regulated down-regulated HER2, HER3 epidermal growth factor receptors
miR-148a down-regulated down-regulated ERBB3 growth factor
miR-148b down-regulated down-regulated ITGA5, ROCK1, PIK3CA, NRAS, CSF1  
miR-181a down-regulated up-regulated ATM stress-sensor kinase
miR-195 down-regulated down-regulated CCNE1 cyclin
miR-196a down-regulated up-regulated ANXA1 apoptosis
miR-320 down-regulated down-regulated TRPC5, NFATC3  
miR-374a down-regulated up-regulated WIF1, PTEN, WNT5A negative regulators of the Wnt/β-catenin signalling cascade
miR-494 up-regulated up-regulated PTEN negative regulator of the Akt/PKB signalling pathway