Fig. 3
From: In vitro characterization of CD133lo cancer stem cells in Retinoblastoma Y79 cell line
CD133lo cells exhibited invasive ability, resistance to Carboplatin treatment and CSC based gene expression signature. a) Graphical representation of the Matrigel Transwell Invasion assay showing the average number of invaded cells in both populations in response to a chemoattractant (p < 0.05). b) CD133lo cells were observed to be more resistant to Carboplatin treatment when compared to CD133hi cells following 48 h exposure (p < 0.05). c) Gene signature of CD133lo cells compared to CD133hi cells with differential expression of stem cell, progenitor, invasion and chemoresistance related genes (p < 0.05) d) Heat map generated for the genes in CD133lo population deregulated by 2-fold change compared to CD133hi cells and hierarchical clustering of CD133lo and hi populations