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Table 6 Logistic regression model with significant methotrexate and corticoid candidate genes

From: Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors

  Extreme phenotype Dyslipidemia
  BAD/rs2286615 (C, DOM, ADD) BAD (CR) APOB/rs676210 (C, DOM) BAD/rs2286615 (C, ADD) BAD (CR)
  OR (95% CI)
p-value
Age 1.219 (1.005-1.478) 1.213 (1.017-1.447) 1.041 (0.971-1.117) 1.047 (0.961-1.141) 1.037 (0.966-1.114)
0.044 0.032 0.259 0.292 0.313
Gender 1.152 (0.216-6.142) 1.624 (0.340-7.749) 0.726 (0.365-1.444) 1.058 (0.453-2.472) 1.043 (0.506-2.151)
0.869 0.543 0.361 0.896 0.908
Corticoid 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000)
0.577 0.355 0.411 0.519 0.571
Asparaginase 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000)
0.714 0.444 0.372 0.704 0.344
Methotrexate 0.999 (0.999-1.000) 0.999 (0.999-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000)
0.075 0.048 0.783 0.225 0.642
CRT 14.506 (1.116-188.530) 16.098 (1.220-212.463) 1.572 (0.619-3.994) 2.361 (0.751-7.425) 2.255 (0.843-6.033)
0.041 0.035 0.341 0.142 0.105
Energy balance 0.999 (0.998-1.001) 1.000 (0.998-1.001) 1.000 (0.999-1.000) 1.000 (0.999-1.000) 1.000 (0.999-1.000)
0.297 0.421 0.469 0.319 0.350
Med score 0.652 (0.319-1.329) 0.752 (0.374-1.513) 1.017 (0.813-1.272) 1.029 (0.793-1.334) 0.984 (0.780-1.240)
0.239 0.425 0.885 0.831 0.888
SNP 57.900 (3.152-1063.462) 69.819 (4.202-1159.995) 0.434 (0.215-0.877) 4.022 (1.441-11.226) 3.560 (1.427-8.882)
0.006 0.003 0.020 0.008 0.006
  Obesity Pre-hypertension Insulin resistance
  BAD/rs2286615 (C, DOM) BAD/rs2286615
(C, ADD)
CRHR1
(R)
CRHR2
(R)
SERPINA6/rs2228541 (C, ADD)
  OR (95% CI)
p-value
Age 0.996 (0.914-1.085) 0.998 (0.916-1.087) 1.010 (0.873-1.169) 0.995 (0.869-1.139) 1.085 (0.993-1.185)
0.926 0.959 0.896 0.940 0.073
Gender 1.979 (0.824-4.750) 2.073 (0.854-5.034) 0.081 (0.009-0.741) 0.165 (0.033-0.809) 1.330 (0.562-3.150)
0.127 0.107 0.026 0.026 0.517
Corticoid 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000)
0.998 0.971 0.828 0.830 0.898
Asparaginase 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000)
0.863 0.824 0.621 0.452 0.141
Methotrexate 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (0.999-1.000) 1.000 (0.999-1.000) 1.000 (1.000-1.000)
0.825 0.786 0.160 0.364 0.935
CRT 1.915 (0.607-6.038) 2.029 (0.636-6.480) 7.685 (0.713-82.885) 3.558 (0.550-23.009) 1.539 (0.463-5.118)
0.267 0.232 0.093 0.183 0.482
Energy balance 1.000 (0.999-1.000) 1.000 (0.999-1.000) 1.000 (0.999-1.001) 0.999 (0.998-1.000) 1.000 (0.999-1.000)
0.137 0.153 0.573 0.168 0.257
Med score 0.921 (0.710-1.195) 0.911 (0.700-1.184) 0.871 (0.562-1.349) 0.806 (0.555-1.170) 0.939 (0.713-1.236)
0.534 0.485 0.536 0.257 0.652
SNP 3.993 (1.410-11.307) 4.044 (1.504-10.879) 76.406 (0.948-6158.616) 3.417 (0.384-30.405) 0.534 (0.286-0.998)
0.009 0.006 0.053 0.271 0.049
  1. Top: Odds ratio (95% CI), bottom: p-value
  2. Boldface: Significant association
  3. C common, CR common/rare, R rare, DOM Dominant effect, ADD Additive effect, CRT Cranial radiotherapy, Med score Mediterranean diet score, Extreme phenotype Three and more cardiometabolic risk factor