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Table 5 Logistic regression model with significant cardiometabolic candidate genes

From: Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors

  Extreme Phenotype Dyslipidemia
  BAD/rs2286615 (C, DOM) FCRL3/rs2282284 (C,DOM) BAD (CR) FCRL3 (CR) OGFOD3/rs62079523 (C, DOM)
  OR (95% CI)
p-value
Age 1.219 (1.005-1.478) 1.151 (0.993-1.334) 1.213 (1.017-1.447) 1.150 (0.993-1.332) 1.033 (0.962-1.109)
0.044 0.062 0.032 0.062 0.374
Gender 1.152 (0.216-6.142) 1.062 (0.268-4.201) 1.624 (0.340-7.749) 1.039 (0.266-4.063) 0.720 (0.360-1.439)
0.869 0.932 0.543 0.956 0.352
Corticoid 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000)
0.577 0.570 0.355 0.574 0.528
Asparaginase 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000) 1.000 (1.000-1.000)
0.714 0.158 0.444 0.270 0.346
Methotrexate 0.999 (0.999-1.000) 1.000 (0.999-1.000) 0.999 (0.999-1.000) 1.000 (0.999-1.000) 1.000 (1.000-1.000)
0.075 0.800 0.048 0.729 0.696
CRT 14.506 (1.116-188.530) 4.938 (0.687-35.491) 16.098 (1.220-212.463) 3.544 (0.561-22.385) 1.708 (0.668-4.366)
0.041 0.112 0.035 0.178 0.264
Energy balance 0.999 (0.998-1.001) 0.999 (0.998-1.000) 1.000 (0.998-1.001) 0.999 (0.999-1.000) 1.000 (0.999-1.000)
0.297 0.304 0.421 0.306 0.210
Med score 0.652 (0.319-1.329) 0.884 (0.518-1.509) 0.752 (0.374-1.513) 0.815 (0.491-1.353) 1.008 (0.807-1.259)
0.239 0.651 0.425 0.430 0.944
SNP 57.900 (3.152-1063.462) 67.983 (3.393-1362.288) 68.819 (4.202-1159.995) 11.695 (1.150-118.907) 2.712 (1.352-5.442)
0.006 0.006 0.003 0.038 0.005
  1. Top: Odds ratio [95% CI], bottom: p-value
  2. Boldface: significant association
  3. C common, CR common/rare, DOM Dominant effect, CRT Cranial radiotherapy, Med score Mediterranean diet score, Extreme phenotype Three and more cardiometabolic risk factor