Skip to main content

Table 5 Logistic regression model with significant cardiometabolic candidate genes

From: Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors

 

Extreme Phenotype

Dyslipidemia

 

BAD/rs2286615 (C, DOM)

FCRL3/rs2282284 (C,DOM)

BAD (CR)

FCRL3 (CR)

OGFOD3/rs62079523 (C, DOM)

 

OR (95% CI)

p-value

Age

1.219 (1.005-1.478)

1.151 (0.993-1.334)

1.213 (1.017-1.447)

1.150 (0.993-1.332)

1.033 (0.962-1.109)

0.044

0.062

0.032

0.062

0.374

Gender

1.152 (0.216-6.142)

1.062 (0.268-4.201)

1.624 (0.340-7.749)

1.039 (0.266-4.063)

0.720 (0.360-1.439)

0.869

0.932

0.543

0.956

0.352

Corticoid

1.000 (1.000-1.000)

1.000 (1.000-1.000)

1.000 (1.000-1.000)

1.000 (1.000-1.000)

1.000 (1.000-1.000)

0.577

0.570

0.355

0.574

0.528

Asparaginase

1.000 (1.000-1.000)

1.000 (1.000-1.000)

1.000 (1.000-1.000)

1.000 (1.000-1.000)

1.000 (1.000-1.000)

0.714

0.158

0.444

0.270

0.346

Methotrexate

0.999 (0.999-1.000)

1.000 (0.999-1.000)

0.999 (0.999-1.000)

1.000 (0.999-1.000)

1.000 (1.000-1.000)

0.075

0.800

0.048

0.729

0.696

CRT

14.506 (1.116-188.530)

4.938 (0.687-35.491)

16.098 (1.220-212.463)

3.544 (0.561-22.385)

1.708 (0.668-4.366)

0.041

0.112

0.035

0.178

0.264

Energy balance

0.999 (0.998-1.001)

0.999 (0.998-1.000)

1.000 (0.998-1.001)

0.999 (0.999-1.000)

1.000 (0.999-1.000)

0.297

0.304

0.421

0.306

0.210

Med score

0.652 (0.319-1.329)

0.884 (0.518-1.509)

0.752 (0.374-1.513)

0.815 (0.491-1.353)

1.008 (0.807-1.259)

0.239

0.651

0.425

0.430

0.944

SNP

57.900 (3.152-1063.462)

67.983 (3.393-1362.288)

68.819 (4.202-1159.995)

11.695 (1.150-118.907)

2.712 (1.352-5.442)

0.006

0.006

0.003

0.038

0.005

  1. Top: Odds ratio [95% CI], bottom: p-value
  2. Boldface: significant association
  3. C common, CR common/rare, DOM Dominant effect, CRT Cranial radiotherapy, Med score Mediterranean diet score, Extreme phenotype Three and more cardiometabolic risk factor