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Table 4 Significant genetic associations with methotrexate and corticosteroid candidate genes

From: Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors

Common Variants
  Gene SNP ID MAF p-value FDR Model
Dyslipidemia BAD rs2286615 0.10 0.00065 0.021 ADD
APOB rs676210 0.23 0.0069 0.110 DOM
Extreme phenotype BAD rs2286615 0.10 0.00034 0.0089 ADD, DOM
Insulin resistance BAD rs2286615 0.10 0.0044 0.069 DOM
SERPINA6 rs2228541 0.50 0.0051 0.069 ADD, DOM, REC
Obesity BAD rs2286615 0.10 0.0025 0.081 ADD, DOM
Rare variants
  Gene Rare (n) p-value FDR
Extreme phenotype NR3C1 2 0.0021 0.17
Pre-hypertension CRHR1 1 0.0025 0.20
CRHR2 2 0.0048 0.20
Common/Rare variants
  Gene Rare (n) Common (n) p-value FDR
Dyslipidemia BAD 3 1 0.00049 0.040
APOB 30 3 0.0028 0.12
CBS 3 0 0.0042 0.12
SLCO4C1 4 0 0.0066 0.14
Extreme phenotype BAD 3 1 3.35x10-5 0.0028
NR3C1 2 0 0.0037 0.15
Pre-hypertension CRHR1 1 0 0.0032 0.14
CRHR2 2 0 0.0033 0.14
  1. MAF Minor allele frequency, DOM Dominant effect, ADD Additive effect, REC Recessive effect, Rare (n) Number of rare variants analyzed in the gene, Common (n) Number of common variants analyzed in the gene, Extreme phenotype Three and more cardiometabolic risk factor