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Table 4 Significant genetic associations with methotrexate and corticosteroid candidate genes

From: Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors

Common Variants

 

Gene

SNP ID

MAF

p-value

FDR

Model

Dyslipidemia

BAD

rs2286615

0.10

0.00065

0.021

ADD

APOB

rs676210

0.23

0.0069

0.110

DOM

Extreme phenotype

BAD

rs2286615

0.10

0.00034

0.0089

ADD, DOM

Insulin resistance

BAD

rs2286615

0.10

0.0044

0.069

DOM

SERPINA6

rs2228541

0.50

0.0051

0.069

ADD, DOM, REC

Obesity

BAD

rs2286615

0.10

0.0025

0.081

ADD, DOM

Rare variants

 

Gene

Rare (n)

p-value

FDR

Extreme phenotype

NR3C1

2

0.0021

0.17

Pre-hypertension

CRHR1

1

0.0025

0.20

CRHR2

2

0.0048

0.20

Common/Rare variants

 

Gene

Rare (n)

Common (n)

p-value

FDR

Dyslipidemia

BAD

3

1

0.00049

0.040

APOB

30

3

0.0028

0.12

CBS

3

0

0.0042

0.12

SLCO4C1

4

0

0.0066

0.14

Extreme phenotype

BAD

3

1

3.35x10-5

0.0028

NR3C1

2

0

0.0037

0.15

Pre-hypertension

CRHR1

1

0

0.0032

0.14

CRHR2

2

0

0.0033

0.14

  1. MAF Minor allele frequency, DOM Dominant effect, ADD Additive effect, REC Recessive effect, Rare (n) Number of rare variants analyzed in the gene, Common (n) Number of common variants analyzed in the gene, Extreme phenotype Three and more cardiometabolic risk factor
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BMC Cancer

ISSN: 1471-2407

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