Skip to main content

Table 2 Results from CPRD (time-varying and non-time-varying covariate analysis by adjustment)

From: Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis

Time-Varying (follow-up from cancer diagnosis)

   

Unadjusted

Adjusted for age

Multivariate Modela

No. of patients

No. Died

HR

95% CI

HR

95% CI

HR

95% CI

All patients

No VTE

12,591

3504

1

  

1

  

1

  

VTE

611

298

2.97

2.62

3.36

2.58

2.27

2.92

2.42

2.13

2.75

Local disease

No VTE

4823

726

1

  

1

  

1

  

VTE

214

81

4.05

3.17

5.16

3.21

2.51

4.1

2.94

2.29

3.77

Regional disease

No VTE

2800

798

1

  

1

  

1

  

VTE

161

89

3.23

2.57

4.05

2.9

2.31

3.64

2.53

2.01

3.19

Distant metastases

No VTE

449

300

1

  

1

  

1

  

VTE

21

14

1.4

0.8

2.47

1.27

0.72

2.24

1.47

0.82

2.63

Unknown stage

No VTE

4519

1680

1

  

1

  

1

  

VTE

215

114

2.45

2

3.01

2.27

1.85

2.78

2.33

1.89

2.87

Non-time-varying (follow-up commencing 6 months after cancer diagnosis)

All patients

No VTE

12,148

3171

1

  

1

  

1

  

VTE

138

54

1.63

1.24

2.14

1.50

1.15

1.96

1.22

0.93

1.60

Local disease

No VTE

4854

743

1

  

1

  

1

  

VTE

45

11

1.72

0.95

3.12

1.51

0.83

2.74

1.25

0.68

2.27

Regional disease

No VTE

2834

834

1

  

1

  

1

  

VTE

46

22

1.73

1.13

2.64

1.53

1

2.34

1.17

0.76

1.79

Distant metastases

No VTE

331

212

1

  

1

  

1

  

VTE

5

3

1.34

0.43

4.18

1.37

0.44

4.3

1.32

0.40

4.35

Unknown stage

No VTE

4129

1382

1

  

1

  

1

  

VTE

42

18

1.37

0.86

2.18

1.34

0.84

2.14

1.23

0.77

1.96

  1. aage plus: stage (where not stratified), grade, comorbidity, tamoxifen therapy, smoking, body mass index, surgery and chemotherapy. In the time-varying analysis, no. died represents the number of deaths in women who never developed VTE
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us