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Table 3 Interaction between ADH1B rs17033, rs4147536, ALDH2 rs671 polymorphisms, smoking, alcohol consumption and BMI in gastric cancer patients

From: Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India

 

Exposure

Status

Genotypes

Control(n-108)

Case (n-105)

OR (95% CI)a

P value

ADH1B

rs17033

Smoking

Non-smoker

AA

64

38

Reference:

 

AG + GG

2

3

3.84 (0.42–35.44)

0.223

Smoker

AA

32

47

Reference:

 

AG + GG

5

17

1.25 (0.33–4.67)

0738

Alcohol

Non-alcoholic

AA

82

57

Reference:

 

AG + GG

3

3

1.79 (0.27–11.68)

0542

Alcoholic

AA

19

28

Reference:

 

AG + GG

4

17

1.63 (0.40–6.60)

0491

Smoking + Alcohol

Both non-smoker and non-alcoholic

AA

64

35

Reference:

 

AG + GG

2

3

3.84 (0.42–35.44)

0.223

Both smoker and alcoholic

AA

19

25

Reference:

 

AG + GG

4

17

1.63 (0.40–6.60)

0.491

BMI

<22

AA

23

53

Reference:

 

AG + GG

4

14

1.79 (0.22–14.79)

0.587

ALDH2

rs671

Smoking

Non-smoker

GG

64

40

Reference:

 

GA + AA

2

1

0.28 (0.01–5.83)

0.396

Smoker

GG

40

48

Reference:

 

GA + AA

2

16

7.58 (1.34–42.78)

0.009

Alcohol

Non-alcoholic

GG

82

57

Reference:

 

GA + AA

3

3

0.69 (0.08–5.62)

0.725

Alcoholic

GG

22

33

Reference:

 

GA + AA

1

7

2.15 (0.20–23.50)

0.512

Smoking +Alcohol

Both non-smoker and non-alcoholic

GG

64

37

Reference:

 

GA + AA

2

1

0.28 (0.01–5.83)

0.396

Both smoker and alcoholic

GG

22

28

Reference:

 

GA + AA

1

14

10.90 (1.16–102.44)

0.010

BMI

<22

GG

25

56

Reference:

 

GA + AA

2

11

1.38 (0.14–14.01)

0.787

ADH1B

rs4147536

Smoking

Non-smoker

GG

36

16

Reference:

 

GT + TT

30

25

1.75 (0.65–4.72)

0262

Smoker

GG

20

46

Reference:

 

GT + TT

22

18

0.41 (0.18–0.97)

0.041

Alcohol

Non-alcoholic

GG

45

33

Reference:

 

GT + TT

40

27

0.62 (0.17–2.20)

0.456

Alcoholic

GG

11

29

Reference:

 

GT + TT

12

16

0.36 (0.08–1.69)

0.188

Smoking +Alcohol

Both non-smoker and non-alcoholic

GG

36

16

Reference:

 

GT + TT

30

22

1.75 (0.65–4.72)

0.262

Both smoker and alcoholic

GG

11

29

Reference:

 

GT + TT

12

13

0.62 (0.17–2.20)

0.456

BMI

<22 Kg/m2

GG

17

41

Reference:

 

GT + TT

10

26

2.81 (0.62–12.62)

0.166

  1. aOdds ratio were adjusted for age, sex, BMI, alcohol and smoking status, p value < 0.05 is considered to be statistically significant
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BMC Cancer

ISSN: 1471-2407

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