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Table 3 Interaction between ADH1B rs17033, rs4147536, ALDH2 rs671 polymorphisms, smoking, alcohol consumption and BMI in gastric cancer patients

From: Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India

  Exposure Status Genotypes Control(n-108) Case (n-105) OR (95% CI)a P value
ADH1B
rs17033
Smoking Non-smoker AA 64 38 Reference:  
AG + GG 2 3 3.84 (0.42–35.44) 0.223
Smoker AA 32 47 Reference:  
AG + GG 5 17 1.25 (0.33–4.67) 0738
Alcohol Non-alcoholic AA 82 57 Reference:  
AG + GG 3 3 1.79 (0.27–11.68) 0542
Alcoholic AA 19 28 Reference:  
AG + GG 4 17 1.63 (0.40–6.60) 0491
Smoking + Alcohol Both non-smoker and non-alcoholic AA 64 35 Reference:  
AG + GG 2 3 3.84 (0.42–35.44) 0.223
Both smoker and alcoholic AA 19 25 Reference:  
AG + GG 4 17 1.63 (0.40–6.60) 0.491
BMI <22 AA 23 53 Reference:  
AG + GG 4 14 1.79 (0.22–14.79) 0.587
ALDH2
rs671
Smoking Non-smoker GG 64 40 Reference:  
GA + AA 2 1 0.28 (0.01–5.83) 0.396
Smoker GG 40 48 Reference:  
GA + AA 2 16 7.58 (1.34–42.78) 0.009
Alcohol Non-alcoholic GG 82 57 Reference:  
GA + AA 3 3 0.69 (0.08–5.62) 0.725
Alcoholic GG 22 33 Reference:  
GA + AA 1 7 2.15 (0.20–23.50) 0.512
Smoking +Alcohol Both non-smoker and non-alcoholic GG 64 37 Reference:  
GA + AA 2 1 0.28 (0.01–5.83) 0.396
Both smoker and alcoholic GG 22 28 Reference:  
GA + AA 1 14 10.90 (1.16–102.44) 0.010
BMI <22 GG 25 56 Reference:  
GA + AA 2 11 1.38 (0.14–14.01) 0.787
ADH1B
rs4147536
Smoking Non-smoker GG 36 16 Reference:  
GT + TT 30 25 1.75 (0.65–4.72) 0262
Smoker GG 20 46 Reference:  
GT + TT 22 18 0.41 (0.18–0.97) 0.041
Alcohol Non-alcoholic GG 45 33 Reference:  
GT + TT 40 27 0.62 (0.17–2.20) 0.456
Alcoholic GG 11 29 Reference:  
GT + TT 12 16 0.36 (0.08–1.69) 0.188
Smoking +Alcohol Both non-smoker and non-alcoholic GG 36 16 Reference:  
GT + TT 30 22 1.75 (0.65–4.72) 0.262
Both smoker and alcoholic GG 11 29 Reference:  
GT + TT 12 13 0.62 (0.17–2.20) 0.456
BMI <22 Kg/m2 GG 17 41 Reference:  
GT + TT 10 26 2.81 (0.62–12.62) 0.166
  1. aOdds ratio were adjusted for age, sex, BMI, alcohol and smoking status, p value < 0.05 is considered to be statistically significant