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Table 4 Comparison of doses to active whole pelvic and lumbar-sacral bone marrow (defined with 18FDG-PET) among the 4 plans

From: Incorporating 18FDG-PET-defined pelvic active bone marrow in the automatic treatment planning process of anal cancer patients undergoing chemo-radiation

   Plan A Plan B Plan C Plan D p ≤ 0.05 ANOVA Fisher-Hayter test
Structure Parameter Mean SD(+/−) Mean SD(+/−) Mean SD(+/−) Mean SD(+/−)   
ACTPBM D max 52.67 2.72 52.93 2.82 53.03 2.79 53.18 2.63 NS  
D mean 29.33 2.38 26.99 2.38 25.76 2.74 26.02 2.69 0.014 A vs C and D
V 5 94.59 4.23 92.85 5.05 92.57 5.32 92.71 5.11 NS  
V 10 87.84 6.04 85.10 7.10 84.05 7.73 84.35 7.53 NS  
V 15 82.82 7.06 78.54 7.52 75.17 9.14 75.82 8.44 NS  
V 20 74.26 7.13 68.58 6.94 63.50 8.59 64.24 8.43 0.015 A vs C and D
V 25 63.49 7.48 56.35 6.90 51.49 7.52 52.18 7.97 0.030 A vs C and D
V 30 52.63 7.17 44.87 6.71 40.27 7.12 41.31 7.71 0.020 A vs C and D
V 35 41.72 6.78 33.35 6.13 30.06 6.43 31.14 6.73 0.010 A vs B,C and D
V 40 28.82 5.67 21.54 5.10 19.94 7.27 20.67 5.24 0.020 A vs B,C and D
V 45 9.16 3.51 7.64 2.75 7.20 2.83 6.91 2.21 NS  
ACTLSBM D max 48.46 2.01 48.66 1.51 49.08 1.70 49.13 1.54 NS  
D mean 37.86 18.56 27.87 4.38 27.35 4.65 27.65 4.40 NS  
V 5 89.89 8.72 87.71 9.16 87.24 9.48 87.43 9.30 NS  
V 10 83.87 8.66 79.88 9.49 79.18 10.58 79.32 10.03 NS  
V 15 79.94 9.09 74.87 9.99 74.19 11.68 74.46 10.64 NS  
V 20 77.23 9.44 68.80 11.31 67.97 13.53 68.45 11.75 NS  
V 25 73.13 10.15 60.88 12.60 59.46 14.15 60.71 12.54 NS  
V 30 66.53 11.19 52.06 13.20 50.07 13.19 51.46 12.97 0.020 A vs B,C and D
V 35 56.95 12.73 42.15 12.79 40.19 11.90 41.42 12.30 0.010 A vs B,C and D
V 40 41.04 14.37 29.81 10.52 28.17 9.40 29.29 9.72 0.050 A vs C
V 45 16.11 12.75 10.53 5.13 9.48 3.92 9.23 3.74 NS  
  1. Legend: D max maximal dose, D mean mean dose, SD standard deviation, V 5,10,15,20,25,30,35,40,45 relative volume receiving 5,10,15,20,25,30,35,40,45 Gy, PBM pelvic bone marrow, LSBM lumbar-sacral bone marrow, ACT active, A, B, C, D plan A,B,C, D, NS non significant