BMC Cancer

Table 3 Comparison of qualitative tests of MET-PET for differentiation between LR and RN in BM

From: Prospective study of ¹¹C–methionine PET for distinguishing between recurrent brain metastases and radiation necrosis: limitations of diagnostic accuracy and long-term results of salvage treatment

First author & year	No. of lesions	LNR cut-off value	Sensitivity (%)	Specificity (%)	AUC
Tsuyuguchi, 2005	21	1.42^a	78	100	NR
Terakawa, 2008	51	1.41^a	79	75	0.78
Minamimoto, 2015	42	1.30^b	82	86	0.89
Present study, 2017	37	1.40^b	82	75	0.84

MET-PET ¹¹C–methionine positron emission tomography, LR local recurrence, RN radiation necrosis, BM brain metastases, LNR lesion/normal ratios, AUC area under the curve, NR not reported
^aSUV_mean (lesion)/SUV_mean (reference), ^bSUV_max (lesion)/SUV_max (reference)

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