Fig. 1

Examples of immunoexpression patterns of PTTG1IP and securin in breast carcinomas. PTTG1IP was observed as a diffuse cytoplasmic staining, and scored based on the extent of positive cancer cells as negative (score 0) and mild to strong positivity (scores 1+ − 3+). Securin was observed both in the nucleus and cytoplasm of the cancer cells and classified according to the fraction of positively-staining cancer cells (<10% vs. ≥10% of cancer cells). Examples of nuclear and cytoplasmic staining patterns are indicated with arrows. (200× magnification)