The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database

Table 3 The association between birth weight and the risk of leukemia

Birth weight	Controls	Leukemia cases	OR	95%CI	P value
Birth weight	Controls	Leukemia cases	OR	Lower	Upper
Total subjects
< 2500 g	24	3	0.7	0.2	2.6	0.564
2500- < 3000 g	137	20	0.7	0.4	1.3	0.300
3000- < 3500 g	305	54	1	Reference
3500–4000 g	276	33	0.7	0.4	1.1	0.092
> 4000 g	80	14	1.1	0.6	2.2	0.752
			P for homogeneity = 0.396 For all: P for trend = 0.778 (beta = 0.00006) For birth weight ≥ 2500 g: P for trend = 0833 (beta = 0.00005) For birth weight 2500–4000 g: P for trend = 0.475 (beta = −0.00022)
< 2500 g	24	3	0.8	0.2	3.0	0.765
2500–4000 g	718	107	1	Reference
> 4000 g	80	14	1.4	0.7	2.6	0.343
			P for homogeneity = 0.611
The risk of high-birth-weight and LGA children compared to normal-birth-weight children^a
2500–4000 g	718	107	1	Reference
> 4000 g and LGA	48	10	1.7	0.8	3.7	0.166
The risk of high-birth-weight and SGA/AGA children compared to normal-birth-weight children^a
2500–4000 g	718	107	1	Reference
> 4000 g and SGA/AGA	32	4	0.9	0.3	2.7	0.865

LGA large for gestational age, SGA small for gestational age, AGA appropriate for gestational age
ORs and corresponding 95%CIs and p values were adjusted for sex, ethnicity, year of birth, age at diagnosis, gestational age (continuous variable), maternal age and DOE sites
^a Children with low-birth weight were not included in the analyses

ISSN: 1471-2407