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Table 3 The association between birth weight and the risk of leukemia

From: The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database

Birth weight Controls Leukemia cases OR 95%CI P value
Lower Upper  
Total subjects
  < 2500 g 24 3 0.7 0.2 2.6 0.564
 2500- < 3000 g 137 20 0.7 0.4 1.3 0.300
 3000- < 3500 g 305 54 1 Reference  
 3500–4000 g 276 33 0.7 0.4 1.1 0.092
  > 4000 g 80 14 1.1 0.6 2.2 0.752
    P for homogeneity = 0.396
For all: P for trend = 0.778 (beta = 0.00006)
For birth weight ≥ 2500 g: P for trend = 0833 (beta = 0.00005)
For birth weight 2500–4000 g: P for trend = 0.475 (beta = −0.00022)
  < 2500 g 24 3 0.8 0.2 3.0 0.765
 2500–4000 g 718 107 1 Reference  
  > 4000 g 80 14 1.4 0.7 2.6 0.343
    P for homogeneity = 0.611
The risk of high-birth-weight and LGA children compared to normal-birth-weight childrena
 2500–4000 g 718 107 1 Reference   
  > 4000 g and LGA 48 10 1.7 0.8 3.7 0.166
The risk of high-birth-weight and SGA/AGA children compared to normal-birth-weight childrena
 2500–4000 g 718 107 1 Reference   
  > 4000 g and SGA/AGA 32 4 0.9 0.3 2.7 0.865
  1. LGA large for gestational age, SGA small for gestational age, AGA appropriate for gestational age
  2. ORs and corresponding 95%CIs and p values were adjusted for sex, ethnicity, year of birth, age at diagnosis, gestational age (continuous variable), maternal age and DOE sites
  3. a Children with low-birth weight were not included in the analyses