The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database

Table 2 The association between birth weight and the risk of CNS tumors

Birth weight	Controls	CNS tumors	OR	95%CI		P value
Birth weight	Controls	CNS tumors	OR	Lower	Upper	P value
Total subjects
< 2500 g	24	7	1.8	0.5	5.8	0.363
2500- < 3000 g	137	7	0.6	0.2	1.4	0.214
3000- < 3500 g	305	21	1	Reference
3500–4000 g	276	25	1.5	0.8	2.8	0.205
> 4000 g	80	12	2.9	1.3	6.6	0.012
			P for homogeneity = 0.017 For all: P for trend = 0.010 (beta = 0.0007) For birth weight ≥ 2500 g:P for trend < 0.001 (beta = 0.0011) For birth weight 2500–4000 g: P for trend = 0.012 (beta = 0.0011)
< 2500 g	24	7	2.0	0.7	5.9	0.241
2500–4000 g	718	53	1	Reference
> 4000 g	80	12	2.5	1.2	5.2	0.018
			P for homogeneity = 0.028
The risk of high-birth-weight and LGA children compared to normal-birth-weight children^a
2500–4000 g	718	53	1	Reference
> 4000 g and LGA	48	8	2.7	1.1	6.2	0.035
The risk of high-birth-weight and SGA/AGA children compared to normal-birth-weight children^a
2500–4000 g	718	53	1	Reference
> 4000 g and SGA/AGA	32	4	2.2	0.7	6.7	0.209

LGA large for gestational age, SGA small for gestational age, AGA appropriate for gestational age
ORs and corresponding 95%CIs and p values were adjusted for sex, ethnicity, year of birth, age at diagnosis, gestational age (continuous variable), maternal age and DOE sites
^a Children with low-birth weight were not included in the analyses

ISSN: 1471-2407