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Table 3 50% inhibitory concentration of compound 1–3 against various cell lines. The compound 3 showed potent anti-cancer activity against NSCLC cells as compared to cisplatin (standard drug)

From: Isolation and characterization of three new anti-proliferative Sesquiterpenes from Polygonum barbatum and their mechanism via apoptotic pathway

 

NCI-H460

MCF-7

HeLa

NIH-3 T3

Compound 1

0.23 mM ± 0.85

Inactive

Inactive

0.42 mM ± 0.13

Compound 2

0.13 mM ± 0.38

Inactive

Inactive

0.28 mM ± 0.5

Compound 3

17.86 μM ± 0.72

11.86 μM ± 0.46

32.13 μM ± 0.6

30.32 μM ± 0.93

Cisplatin

19 μM ± 1.24

09.62 μM ± 0.5

16.19 μM ± 0.7