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Table 1 Patient and tumour characteristics according to Ki67 expression or uPA/PAI-1 status (n = 347)

From: Assessment of Ki67 and uPA/PAI-1 expression in intermediate-risk early stage breast cancers

  Age, Years Menopausal status Tumour classification Hormonal status HER2 status Clinicopathological subtypes Histological type Histological grade
  n (%) Median (range) Premenopausal Postmenopausal T1 T2 T3 T4 ER+/PR + ER+/PR- ER−/PR+ ER−/PR- Negative Positive Luminal A Luminal B HER2-negative Luminal B HER2-positive HER2-positive Triple-negative Invasive ductal carcinoma Invasive ductal + lobular carcinoma Invasive lobular carcinoma Other I II III
Total   347 62
(33–87)
85
(25)
262
(75)
231
(66)
108
(31)
6
(2)
2
(1)
260
(75)
62
(18)
0
(0)
25
(7)
333
(96)
14
(4)
190
(55)
120
(34)
12
(3)
2
(1)
23
(7)
245
(71)
12
(3)
68
(20)
22
(6)
74
(21)
227
(66)
46
(13)
Ki67 status Low 250
(72)
61.5
(33–87)
60
(24)
190
(76)
178
(71)
65
(26)
5
(2)
2
(1)
196
(78)
49
(20)
0
(0)
5
(2)
242
(97)
8
(3)
189
(76)
48
(19)
8
(3)
0
(0)
5
(2)
160
(64)
10
(4)
59
(24)
21
(9)
71
(28)
170
(68)
9
(4)
High 97
(28)
61
(36–85)
25
(25)
72
(75)
53
(55)
43
(44)
1
(1)
0
(0)
64
(66)
13
(13)
0
(0)
20
(21)
91
(94)
6
(6)
1
(1)
72
(74)
4
(4)
2
(2)
18
(19)
85
(88)
2
(2)
9
(9)
1
(1)
3
(3)
57
(59)
37
(38)
P-value   0.7 0.02 <0.0001 0.1 <0.0001 <0.0001 <0.0001
uPA/PAI-1 status Negative 135
(39)
60
(38–87)
40
(30)
95
(70)
79
(59)
53
(39)
2
(1)
1
(1)
99
(74)
30
(22)
0
(0)
6
(4)
131
(97)
4
(3)
77
(57)
49
(36)
3
(2)
1
(1)
5
(4)
86
(64)
8
(6)
32
(24)
9
(7)
36
(27)
85
(63)
14
(10)
Positive 212
(61)
61
(33–86)
45
(21)
167
(89)
152
(71)
55
(26)
4
(2)
1
(1)
161
(76)
32
(15)
0
(0)
19
(9)
202
(95)
10
(5)
113
(53)
71
(33)
9
(4)
1
(1)
18
(9)
159
(75)
4
(19)
36
(17)
13
(7)
38
(18)
142
(67)
32
(15)
P-value   0.07 0.08 0.09 0.5 <0.001 0.1 0.1
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