Table 1 Patient and tumour characteristics according to Ki67 expression or uPA/PAI-1 status (n = 347)
From: Assessment of Ki67 and uPA/PAI-1 expression in intermediate-risk early stage breast cancers
Age, Years | Menopausal status | Tumour classification | Hormonal status | HER2 status | Clinicopathological subtypes | Histological type | Histological grade | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n (%) | Median (range) | Premenopausal | Postmenopausal | T1 | T2 | T3 | T4 | ER+/PR + | ER+/PR- | ER−/PR+ | ER−/PR- | Negative | Positive | Luminal A | Luminal B HER2-negative | Luminal B HER2-positive | HER2-positive | Triple-negative | Invasive ductal carcinoma | Invasive ductal + lobular carcinoma | Invasive lobular carcinoma | Other | I | II | III | ||
Total | 347 | 62 (33–87) | 85 (25) | 262 (75) | 231 (66) | 108 (31) | 6 (2) | 2 (1) | 260 (75) | 62 (18) | 0 (0) | 25 (7) | 333 (96) | 14 (4) | 190 (55) | 120 (34) | 12 (3) | 2 (1) | 23 (7) | 245 (71) | 12 (3) | 68 (20) | 22 (6) | 74 (21) | 227 (66) | 46 (13) | |
Ki67 status | Low | 250 (72) | 61.5 (33–87) | 60 (24) | 190 (76) | 178 (71) | 65 (26) | 5 (2) | 2 (1) | 196 (78) | 49 (20) | 0 (0) | 5 (2) | 242 (97) | 8 (3) | 189 (76) | 48 (19) | 8 (3) | 0 (0) | 5 (2) | 160 (64) | 10 (4) | 59 (24) | 21 (9) | 71 (28) | 170 (68) | 9 (4) |
High | 97 (28) | 61 (36–85) | 25 (25) | 72 (75) | 53 (55) | 43 (44) | 1 (1) | 0 (0) | 64 (66) | 13 (13) | 0 (0) | 20 (21) | 91 (94) | 6 (6) | 1 (1) | 72 (74) | 4 (4) | 2 (2) | 18 (19) | 85 (88) | 2 (2) | 9 (9) | 1 (1) | 3 (3) | 57 (59) | 37 (38) | |
P-value | 0.7 | 0.02 | <0.0001 | 0.1 | <0.0001 | <0.0001 | <0.0001 | ||||||||||||||||||||
uPA/PAI-1 status | Negative | 135 (39) | 60 (38–87) | 40 (30) | 95 (70) | 79 (59) | 53 (39) | 2 (1) | 1 (1) | 99 (74) | 30 (22) | 0 (0) | 6 (4) | 131 (97) | 4 (3) | 77 (57) | 49 (36) | 3 (2) | 1 (1) | 5 (4) | 86 (64) | 8 (6) | 32 (24) | 9 (7) | 36 (27) | 85 (63) | 14 (10) |
Positive | 212 (61) | 61 (33–86) | 45 (21) | 167 (89) | 152 (71) | 55 (26) | 4 (2) | 1 (1) | 161 (76) | 32 (15) | 0 (0) | 19 (9) | 202 (95) | 10 (5) | 113 (53) | 71 (33) | 9 (4) | 1 (1) | 18 (9) | 159 (75) | 4 (19) | 36 (17) | 13 (7) | 38 (18) | 142 (67) | 32 (15) | |
P-value | 0.07 | 0.08 | 0.09 | 0.5 | <0.001 | 0.1 | 0.1 | ||||||||||||||||||||