Table 3 Primary pharmacokinetic parameters for LJM716 3–40 mg/kg QW (Cycle 1 Day 1)
|  | 3 mg/kg QW n = 1 | 10 mg/kg QW n = 5 | 20 mg/kg QW n = 6 | 40 mg/kg QW n = 6 | 40 mg/kg QW EX, n = 30 | 20 mg/kg Q2W n = 6 |
|---|---|---|---|---|---|---|
AUClast, h*μg/mLa | 6158 (−) | 21,302 (3731) | 32,791 (9635) | 74,637 (7182) | 73,360 (18,819) | 52,659 (23,302) |
Cmax, μg/mL | 65.2 (−) | 204 (23.6) | 369 (131) | 839 (143) | 706 (129) | 408 (137) |
Tmax, h | 2.18 (2.18–2.18) | 4.00 (2.13–4.53) | 3.88 (2.08–5.33) | 4.34 (2.42–8.42) | 3.79 (2.05–7.5) | 3.25 (2.08–4.03) |
Tlast, h | 168 (168–168) | 170 (166–171) | 167 (146–169) | 167 (166–191) | 166 (7.22–171) | 334 (261–336) |
Clast, μg/mL | 21.4 (−) | 80.3 (18.4) | 115.0 (28.6) | 296.0 (66.0) | 236.0 (79.7) | 82.0 (46.6) |