Fig. 7From: Circadian disruption promotes tumor growth by anabolic host metabolism; experimental evidence in a rat modelIn tumors from rats exposed to LL the expression of genes involved in lipogenesis, glucose uptake, angiogenesis and cell proliferation was increased. (a) Relative expression of genes (Acaca, Fasn, Srebp-1 and Pparγ) involved in lipogenesis; (b) Relative expression of genes involved in lipid oxidation (Cpt1, Acads, Hadha and Pparα); (c) glycolysis (Glut-1, HkII, Pkm2, Ldh); (d) Tumor growth (Myc, P53, Ir); (e) angiogenesis (Vegfα, Hif1-α) and (F) cytokines (Tfgα, Il10, IL6, Il1α and Tnfα). All genes were measured using qRT-PCR analysis. Gene expression in tumors was normalized to the expression of Hprt and Tbp as endogenous controls. Data are plotted as the mean ± SEM. (n = 7–10/group). *p < 0.05, *p < 0.01 indicates statistical difference from LD; unpaired t testBack to article page