Programmed cell death ligand 1 cut-point is associated with reduced disease specific survival in resected pancreatic ductal adenocarcinoma

Table 2 Multivariable disease specific survival analysis for PD-L1 expression quantified by percent positive & H-score

Variable	Comparison	Risk ratio	95%CI	p-value
PD-L1 H-Score
PD-L1 H-Score	Per unit change	1.01	0.997–1.02	0.10
Age at Surgery	Per unit change	1.01	0.991–1.02	0.44
Sex	Male v Female	1.14	0.85–1.53	0.37
Adjuvant Chemotherapy	Given v Observation	0.59	0.42–0.81	0.0011
Histopathologic Grade	1 v 2	0.63	0.10–2.10	0.50
	1 v 3	0.49	0.08–1.67	0.28
	2 v 3	0.77	0.55–1.09	0.13
Lymphovascular Invasion	Present v Absent	1.27	0.93–1.74	0.13
Perineural Invasion	Present v Absent	1.66	0.96–3.09	0.07
pN-Stage	1 v 0	1.83	1.27–2.68	0.0010
Resection Status	R0 v R1	0.67	0.49–0.94	0.0202
PD-L1 Percent Positive
PD-L1 Percent Positive	Per unit change	1.03	1.0005–1.05	0.0466
Age at Surgery	Per unit change	1.0006	0.99–1.02	0.42
Sex	Male v Female	1.16	0.86–1.55	0.33
Adjuvant Chemotherapy	Given v Observation	0.58	0.42–0.80	0.0008
Histopathologic Grade	1 v 2	0.64	0.10–2.13	0.51
	1 v 3	0.50	0.08–1.71	0.30
	2 v 3	0.78	0.56–1.10	0.15
Lymphovascular Invasion	Present v Absent	1.28	0.94–1.76	0.12
Perineural Invasion	Present v Absent	1.68	0.98–3.13	0.06
pN-Stage	1 v 0	1.85	1.28–2.71	0.0009
Rescetion Status	R0 v R1	0.68	0.49–0.95	0.0189

ISSN: 1471-2407