Table 2 Univariate and multivariate analyses of factors associated with OS and TTR (n = 240)
From: FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway
Variables | OS | TTR | ||||
|---|---|---|---|---|---|---|
Multivariate | Multivariate | |||||
Univariate P | HR (95.0% CI) | P | Univariate P | HR (95.0% CI) | P | |
Age, >50 vs. ≤50 years | 0.169 | NA | 0.289 | NA | ||
Gender, Male vs. Female | 0.259 | NA | 0.084 | NA | ||
HBsAg, Positive vs. negative | 0.264 | NA | 0.171 | NA | ||
Liver cirrhosis, Yes vs. No | 0.019 | 1.77 (0.89–3.52) | 0.104 | 0.150 | NA | |
Serum AFP, >20 vs. ≤20 ng/mL | <0.001 | 1.23 (0.80–1.88) | 0.350 | 0.002 | 1.31 (0.88–1.94) | 0.181 |
Tumor size, >5 vs. ≤ 5 cm | <0.001 | 1.16 (0.56–2.43) | 0.692 | <0.001 | 1.57 (0.75–3.26) | 0.231 |
Tumor number, Multiple vs. Single | 0.001 | 1.78 (1.13–2.80) | 0.013 | <0.001 | 2.34 (1.48–3.70) | <0.001 |
Tumor encapsulation, No vs. Yes | 0.011 | 1.06 (0.73–1.53) | 0.770 | <0.001 | 1.54 (1.07–2.22) | 0.021 |
Vascular invasion, Yes vs. No | <0.001 | 4.42 (2.26–8.63) | <0.001 | <0.001 | 4.28 (2.30–7.97) | <0.001 |
Tumor differentiation, III/IV vs. I/II | 0.002 | 1.74 (1.20–2.53) | 0.004 | 0.077 | NA | |
TNM stage, II /III vs. I | <0.001 | 0.72 (0.35–1.51) | 0.389 | <0.001 | 0.73 (0.37–1.45) | 0.368 |
BCLC stage, B/C vs. 0/A | <0.001 | 1.30 (0.59–2.86) | 0.521 | <0.001 | 0.76 (0.35–1.64) | 0.478 |
FOXP3, High vs. Low | 0.003 | 0.64 (0.44–0.92) | 0.017 | 0.001 | 0.66 (0.46–0.95) | 0.027 |