Skip to main content

Table 2 Univariate and multivariate analyses of factors associated with OS and TTR (n = 240)

From: FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway

Variables OS TTR
  Multivariate   Multivariate
Univariate P HR (95.0% CI) P Univariate P HR (95.0% CI) P
Age, >50 vs. ≤50 years 0.169 NA   0.289 NA  
Gender, Male vs. Female 0.259 NA   0.084 NA  
HBsAg, Positive vs. negative 0.264 NA   0.171 NA  
Liver cirrhosis, Yes vs. No 0.019 1.77 (0.89–3.52) 0.104 0.150 NA  
Serum AFP, >20 vs. ≤20 ng/mL <0.001 1.23 (0.80–1.88) 0.350 0.002 1.31 (0.88–1.94) 0.181
Tumor size, >5 vs. ≤ 5 cm <0.001 1.16 (0.56–2.43) 0.692 <0.001 1.57 (0.75–3.26) 0.231
Tumor number, Multiple vs. Single 0.001 1.78 (1.13–2.80) 0.013 <0.001 2.34 (1.48–3.70) <0.001
Tumor encapsulation, No vs. Yes 0.011 1.06 (0.73–1.53) 0.770 <0.001 1.54 (1.07–2.22) 0.021
Vascular invasion, Yes vs. No <0.001 4.42 (2.26–8.63) <0.001 <0.001 4.28 (2.30–7.97) <0.001
Tumor differentiation, III/IV vs. I/II 0.002 1.74 (1.20–2.53) 0.004 0.077 NA  
TNM stage, II /III vs. I <0.001 0.72 (0.35–1.51) 0.389 <0.001 0.73 (0.37–1.45) 0.368
BCLC stage, B/C vs. 0/A <0.001 1.30 (0.59–2.86) 0.521 <0.001 0.76 (0.35–1.64) 0.478
FOXP3, High vs. Low 0.003 0.64 (0.44–0.92) 0.017 0.001 0.66 (0.46–0.95) 0.027