Table 1 Correlation between FOXP3 expressin in tumor cells and clinicopathologic characteristics (n = 240)
From: FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway
Variables | FOXP3 staining | P | |
|---|---|---|---|
Low (n = 125) | High (n = 115) | ||
n (%) | n (%) | ||
Age (years) | |||
≤ 50 | 59 (47.2) | 53 (46.1) | 0.897 |
> 50 | 66 (52.8) | 62 (53.9) | |
Gender | |||
Male | 103 (82.4) | 101 (87.8) | 0.280 |
Female | 22 (17.6) | 14 (12.2) | |
HBsAg | |||
Negative | 10 (8.0) | 7 (6.1) | 0.622 |
Positive | 115 (92.0) | 108 (93.9) | |
Liver cirrhosis | |||
No | 12 (9.6) | 16 (13.9) | 0.321 |
Yes | 113 (90.4) | 99 (86.1) | |
Serum AFP (ng/mL) | |||
≤ 20 | 34 (27.2) | 48 (41.7) | 0.021 |
> 20 | 91 (72.8) | 67 (58.3) | |
Tumor size (cm) | |||
≤ 5 | 57 (45.6) | 60 (52.2) | 0.366 |
> 5 | 68 (54.4) | 55 (47.8) | |
Tumor number | |||
Single | 98 (78.4) | 86 (74.8) | 0.543 |
Multiple | 27 (21.6) | 29 (25.2) | |
Tumor encapsulation | |||
Yes | 58 (46.4) | 61 (53.0) | 0.366 |
No | 67 (53.6) | 54 (47.0) | |
Vascular invasion | |||
No | 53 (42.4) | 72 (62.6) | 0.002 |
Yes | 72 (57.6) | 43 (37.4) | |
Tumor differentiation | |||
I/II | 71 (56.8) | 64 (55.7) | 0.897 |
III/IV | 54 (43.2) | 51 (44.3) | |
BCLC | |||
0/A | 54 (43.2) | 60 (52.2) | 0.196 |
B/C | 71 (56.8) | 55 (47.8) | |
TNM stage | |||
I | 46 (36.8) | 60 (52.2) | 0.019 |
II/III | 79 (63.2) | 55 (47.8) | |