Skip to main content

Table 3 Correlation of hypermethylation with clinicopathological variables (associations approaching significance, p < 0.05 in bold)

From: BRCA2 carriers with male breast cancer show elevated tumour methylation

  GSTP1 RASSF1A MAL RUNX3 RARβ APC FOXC1 AMI (median)
Hypermethylation + - + - + - + - + - + - + - > <
Age (years)      59.1 65.7    67.2 60.9 69.1 60.4     
p-value       0.04     0.07   0.01     
Tumour size (mm)          22.3 16.5 21.4 17.1    20.8 15.8
p-value           0.01   0.08     0.02
IC-NST Histology        94% 69%         
p-value         0.046         
Grade 3 51% 18%               
p-value   0.09               
Paget’s Disease          31% 8%       
p-value           0.04       
DCIS present    33% 6%             
p-value     0.02             
Lymphovascular invasion 49% 18%          20% 51% 53% 40%   
p-value   0.09           0.07   0.09   
Perineural invasion          63% 36%       
p-value           0.07       
Node positive    52% 24%      62% 34%       
p-value     0.08       0.07       
HER2 positive                13% 0
p-value                 0.11