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Table 1 Association between expression level of GPR155 mRNA and clinicopathological parameters in 144 patients with hepatocellular carcinoma

From: Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma

Clinicopathological parameters Downregulation of GPR155 (n = 57) Others (n = 87) p value
Age 0.349
  < 65 year 23 42
  ≥ 65 year 34 45
Gender 0.013*
 Female 4 19
 Male 53 68
Background liver 0.188
 Normal liver 2 8
 Chronic hepatitis 37 45
 Cirrhosis 18 34
Pugh-Child’s classification 0.044*
 A 50 84
 B 7 3
Hepatitis virus 0.757
 Absent 9 18
 HBV 15 22
 HCV 33 47
AFP (ng/ml) 0.002*
  ≤ 20 22 56
  > 20 35 31
PIVKA II (mAU/ml) 0.002*
  ≤ 40 14 44
  > 40 43 43
Tumor multiplicity 0.078
 Solitary 40 72
 Multiple 17 15
Tumor size 0.120
  < 3.0 cm 14 32
  ≥ 3.0 cm 43 55
Differentiation 0.009*
 Well 7 28
 Moderate 43 55
 Poor 7 4
Growth type 0.495
 Expansive growth 46 74
 Invasive growth 11 13
Serosal infiltration 0.031*
 Absent 49 60
 Present 23 12
Formation of capsule <0.001*
 Absent 33 76
 Present 24 11
Infiltration to capsule 0.035*
 Absent 20 46
 Present 37 41
Septum formation 0.036*
 Absent 14 36
 Present 43 51
Vascular invasion <0.001*
 Absent 34 74
 Present 23 13
UICC pathological stage <0.001*
 I 25 65
 II 22 15
 III 10 7
  1. Abbreviations: HBV hepatitis B virus, HCV hepatitis C virus, AFP α-fetoprotein, PIVKA protein induced by vitamin K antagonists, UICC Union for International Cancer Control. *Statistically significant difference (p < 0.05)