|  | Before matching | After matching | ||||
---|---|---|---|---|---|---|---|
Overall n = 339 (%) | No AC n = 87 (%) | AC n = 252 (%) | p-value | No AC n = 87 (%) | AC n = 87 (%) | p-value | |
Median age (range), years | 59.6 (27.2–85.7) | 65.9 (36.0–85.7) | 58.3 (27.2–84.6) | <0.001 | 65.9 (36.0–85.7) | 63.7 (39.1–84.6) | 0.251 |
Sex | Â | Â | Â | 0.752 | Â | Â | 0.602 |
 Male | 246 (72.6) | 62 (71.3) | 184 (73.0) |  | 62 (71.3) | 59 (67.8) |  |
 Female | 93 (27.4) | 25 (28.7) | 68 (27.0) |  | 25 (28.7) | 28 (32.2) |  |
Distance from AV (cm) | Â | Â | Â | Â | Â | Â | 0.342 |
 ≥ 10.0 | 35 (10.3) | 8 (9.2) | 27 (10.7) |  | 8 (9.2) | 9 (10.3) |  |
 5.0–9.9 | 140 (41.3) | 33 (37.9) | 107 (42.5) |  | 33 (37.9) | 40 (46.0) |  |
 < 5.0 | 164 (48.4) | 46 (52.9) | 118 (46.8) |  | 46 (52.9) | 38 (43.7) |  |
Differentiation | Â | Â | Â | 0.176 | Â | Â | 0.300 |
 Well | 70 (20.6) | 17 (19.5) | 53 (21.0) |  | 17 (19.5) | 20 (23.0) |  |
 Moderate | 248 (73.2) | 61 (70.1) | 187 (74.2) |  | 61 (70.1) | 62 (71.3) |  |
 Poor, mucinous | 21 (6.2) | 9 (10.3) | 12 (4.8) |  | 9 (10.3) | 5 (5.7) |  |
Pretreatment CEA (ng/mL) | Â | Â | Â | 0.621 | Â | Â | 0.413 |
 < 5 | 214 (63.1) | 53 (60.9) | 161 (63.9) |  | 53 (60.9) | 58 (66.7) |  |
 ≥ 5 | 125 (36.9) | 34 (39.1) | 91 (36.1) |  | 34 (39.1) | 29 (33.3) |  |
Surgical procedure | Â | Â | Â | 0.573 | Â | Â | 0.350 |
 LAR | 298 (87.9) | 75 (86.2) | 232 (88.5) |  | 75 (86.2) | 79 (90.8) |  |
 APR | 41 (12.1) | 12 (13.8) | 29 (11.5) |  | 12 (13.8) | 8 (9.2) |  |
Stage | Â | Â | Â | <0.001 | Â | Â | 0.383 |
 ypT0 | 90 (26.5) | 40 (46.0) | 50 (19.8) |  | 40 (46.0) | 37 (42.5) |  |
 ypT1 | 19 (5.6) | 6 (6.9) | 13 (5.2) |  | 6 (6.9) | 4 (4.6) |  |
 ypT2 | 96 (28.3) | 25 (28.7) | 71 (28.2) |  | 25 (28.7) | 26 (29.9) |  |
 ypT3 | 134 (39.5) | 16 (18.4) | 118 (46.8) |  | 16 (18.4) | 20 (23.0) |  |
LN dissected | Â | Â | Â | 0.146 | Â | Â | 0.538 |
 < 12 | 145 (42.8) | 43 (49.4) | 102 (40.5) |  | 43 (49.4) | 39 (44.8) |  |
 ≥ 12 | 194 (57.2) | 44 (50.6) | 150 (59.5) |  | 44 (50.6) | 48 (55.2) |  |
LVI/PNI | Â | Â | Â | 0.812 | Â | Â | 0.657 |
 Negative | 278 (82.0) | 71 (81.6) | 207 (82.1) |  | 71 (81.6) | 80 (92.0) |  |
 Positive | 15 (4.4) | 3 (3.4) | 12 (4.8) |  | 3 (3.5) | 2 (2.3) |  |
 NA | 46 (13.6) | 13 (14.9) | 33 (13.1) |  | 13 (14.9) | 5 (5.8) |  |
Margin | Â | Â | Â | 0.677 | Â | Â | 1.000 |
 Negative | 329 (97.1) | 85 (97.7) | 244 (96.8) |  | 85 (97.7) | 85 (97.7) |  |
 Positive | 10 (2.9) | 2 (2.3) | 8 (3.2) |  | 2 (2.3) | 2 (2.3) |  |
Mandard regression grade | Â | Â | Â | <0.001 | Â | Â | 0.926 |
 Grade 1 | 90 (26.5) | 40 (46.0) | 50 (19.8) |  | 40 (46.0) | 37 (42.5) |  |
 Grade 2 | 90 (26.5) | 17 (19.5) | 73 (29.0) |  | 17 (19.5) | 22 (25.3) |  |
 Grade 3 | 78 (23.0) | 11 (12.6) | 67 (26.6) |  | 11 (12.6) | 15 (17.2) |  |
 Grade 4 | 36 (10.6) | 6 (6.9) | 30 (11.9) |  | 6 (6.9) | 8 (9.2) |  |
 NA | 45 (13.3) | 13 (14.9) | 32 (12.7) |  | 13 (14.9) | 5 (5.8) |  |