Table 3 Summary of patient outcomes in 5 studies comparing LP and TL in advanced laryngeal tumors
Study | T4 patients assigned to conservative treatment arm | T4 patients eventually treated by primary CRT or RT | Comments |
|---|---|---|---|
43 | Unclear, 19 < N < 43 | 59 TL in 116 T1-T4 patients in the conservative treatment arm, 30 upfront 24 TL (upfront + salvage) in 43 T4 patients TL in T4: 56% TL in T1–3: 29% T4 had 5.6-fold lower probability to achieve response to ICT T4 had 7.1-fold poorer organ preservation rate than T1–3 | |
EORTC [1] | 4 | 0 | No T4 patient in the chemo arm eventually received conservative treatment, i.e. upfront TL followed by RT was the treatment for all T4 patients in the surgery as well as in the chemo arm |
GETTEC [15] | 0 | 0 | Only T3 patients were included TL in 58% of patients of ICT arm OS after CRT significantly poorer than after surgery (p = 0.006) |
Bhalavat [16] | 2 | 2 | 1 local recurrence after partial remission 1 survived for 5 years |
RTOG 91–11 | 18 ICRT 17 CCRT 16 RT | Unclear | No T4 tumor with penetration through the cartilage, cartilage at the most minimally eroded 7 upfront TL in ICRT No data given about T category No differential data given for T4 |