Table 1 Summary of hereditary cancer registries from Latin America LS families
Latin American Institutions | Number of families | Number of individuals | Families fulfillinga | Path_MMR carriers (%) | Path_MMR families fulfilling | Age at CRC diagnosis (mean ± SD) | Age at endometrial cancer diagnosis (mean ± SD) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMSII | Revised Bethesda | Other criteria | Path_MMR carriers | Path_MMR non-carriers | Path_MLH1 carriers | Path_MSH2 carriers | Path_MSH6 carriers | Path_PMS2 carriers | Path_EPCAM carriers | AMSII | Revised Bethesda | Other criteria | |||||
Barretos Cancer Hospital (São Paulo, Brazil) | 125 | 369 | 15 | 95 | 30 | 172 (46.6) | 197 (53.4) | 79 (45.9) | 51 (29.7) | 32 (18.6) | 10 (5.8) | 0 | 12 | 48 | 10 | na | na |
Clinica Las Condes (Santiago, Chile) | 100 | 212 | 44 | 47 | 9 | 82 (38.7) | 130 (61.3) | 63 (76.8) | 14 (17.1) | 0 | 2 (2.4) | 3 (3.7) | 24 | 4 | 0 | 40 (10.5) | 48.8 (11.5) |
Hospital de las Fuerzas Armadas (Montevideo, Uruguay) | 29 | 177 | 26 | 1 | 2 | 101 (57.1) | 76 (42.9) | 55 (54.5) | 39 (38.6) | 7 (6.9) | 0 | 0 | 19 | 0 | 0 | 39.9 (9.6) | 44.4 (11.9) |
Hospital Italiano (Buenos Aires, Argentina) | 54 | 75 | 35 | 14 | 5 | 26 (34.7) | 49 (65.3) | 11 (42.3) | 15 (57.7) | 0 | 0 | 0 | 18 | 0 | 0 | 45.8 (7.01) | 43.8 (7.08) |
Hospital Español de Rosario (Rosario, Argentina) | 13 | 25 | 6 | 7 | 0 | 16 (64) | 9 (36) | 5 (31.3) | 10 (62.5) | 0 | 1 (6.2) | 0 | 6 | 2 | 0 | 40.4 (10.4) | 51 (na) |
Hospital das Clinicas (Porto Alegre, Brazil) | 18 | 18 | 12 | 6 | 0 | 11(61.1) | 7 (38.9) | 8 (72.7) | 3 (27.3) | 0 | na | 0 | 11 | 0 | 0 | 42.1 (7.8) | na |
Clinica del Country (Bogota, Colombia) | 5 | 5 | 4 | 0 | 1 | 2 (40) | 3 (60) | 0 | 1 (50) | 0 | 1 (50) | 0 | 1 | 0 | 1 | 32 (na) | na |
Total | 344 | 881 | 142 | 170 | 47 | 410 (46.5) | 471 (53.5) | 221 (53.9) | 133 (32.4) | 39 (9.5) | 14 (3.4) | 3 (0.8) | 91 | 54 | 11 | Â | Â |