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Table 1 Summary of hereditary cancer registries from Latin America LS families

From: A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America

Latin American Institutions Number of families Number of individuals Families fulfillinga Path_MMR carriers (%) Path_MMR families fulfilling Age at CRC diagnosis (mean ± SD) Age at endometrial cancer diagnosis (mean ± SD)
AMSII Revised Bethesda Other criteria Path_MMR carriers Path_MMR non-carriers Path_MLH1 carriers Path_MSH2 carriers Path_MSH6 carriers Path_PMS2 carriers Path_EPCAM carriers AMSII Revised Bethesda Other criteria
Barretos Cancer Hospital (São Paulo, Brazil) 125 369 15 95 30 172 (46.6) 197 (53.4) 79 (45.9) 51 (29.7) 32 (18.6) 10 (5.8) 0 12 48 10 na na
Clinica Las Condes (Santiago, Chile) 100 212 44 47 9 82 (38.7) 130 (61.3) 63 (76.8) 14 (17.1) 0 2 (2.4) 3 (3.7) 24 4 0 40 (10.5) 48.8 (11.5)
Hospital de las Fuerzas Armadas (Montevideo, Uruguay) 29 177 26 1 2 101 (57.1) 76 (42.9) 55 (54.5) 39 (38.6) 7 (6.9) 0 0 19 0 0 39.9 (9.6) 44.4 (11.9)
Hospital Italiano (Buenos Aires, Argentina) 54 75 35 14 5 26 (34.7) 49 (65.3) 11 (42.3) 15 (57.7) 0 0 0 18 0 0 45.8 (7.01) 43.8 (7.08)
Hospital Español de Rosario (Rosario, Argentina) 13 25 6 7 0 16 (64) 9 (36) 5 (31.3) 10 (62.5) 0 1 (6.2) 0 6 2 0 40.4 (10.4) 51 (na)
Hospital das Clinicas (Porto Alegre, Brazil) 18 18 12 6 0 11(61.1) 7 (38.9) 8 (72.7) 3 (27.3) 0 na 0 11 0 0 42.1 (7.8) na
Clinica del Country (Bogota, Colombia) 5 5 4 0 1 2 (40) 3 (60) 0 1 (50) 0 1 (50) 0 1 0 1 32 (na) na
Total 344 881 142 170 47 410 (46.5) 471 (53.5) 221 (53.9) 133 (32.4) 39 (9.5) 14 (3.4) 3 (0.8) 91 54 11   
  1. asome families meet more than one clinical criteria; LS: Lynch syndrome; CRC: colorectal cancer; MMR: mismatch repair; SD: standard deviation; na: not applied; Path_MMR: Pathogenic (disease-causing) variant of an MMR gene; path_MLH1: pathogenic variant of the MLH1 gene; path_MSH2: pathogenic variant of the MSH2 gene; path_MSH6: pathogenic variant of the MSH6 gene; path_PMS2: pathogenic variant of the PMS2 gene
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