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Table 1 Relationship between LINE-1 methylation level and clinicopathological parameters

From: Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma

  No. Average SD P-value
Sex
 M 121 75.48 7.173 0.233
 F 51 76.97 8.216  
Age
 <64 years 87 75.97 8.274 0.936
 ≥64 years 85 75.87 6.674  
Gross type
 Mass forming 141 75.66 7.616 0.702 (ANOVA)
 Periductal infiltrative 8 78.62 3.790 0.558 (KW)
 Intraductal growth 18 76.73 7.110  
 Mixed 5 76.16 10.837  
Multiplicity
 single 147 75.73 7.898 0.422
 multiple 25 77.04 4.501  
T stage
 pT1 48 78.08 6.972 0.049 (ANOVA)
 pT2a 38 73.08 9.417 0.012 (KW)
 pT2b 14 76.12 4.010  
 pT3 47 76.04 7.026  
 pT4 25 75.74 6.622  
N stage
 pN0 133 75.96 7.861 0.899
 pN1 39 75.78 6.223  
M stage
 pM0 161 76.17 7.593 0.095
 pM1 11 72.26 4.972 0.035 (MWa)
TNM stage
 I 40 77.81 7.579 0.229
 II 37 74.42 8.747  
 III 30 76.25 7.801  
 IV 65 75.45 6.406  
Differentiation
 Well 23 79.69 4.766 0.014
 Moderate 94 75.95 6.857  
 Poorly 55 74.28 8.906  
Neural invasion
 Absent 118 75.77 8.146 0.701
 Present 54 76.25 5.921  
Lymphatic invasion
 Absent 102 76.92 7.200 0.034
 Present 70 74.46 7.749  
Vascular invasion
 Absent 95 76.44 8.141 0.396
 Present 77 75.27 6.631 0.047 (MWa)
Chronic liver disease
 Absent 130 75.95 7.497 0.936
 Present 42 75.84 7.617  
Chronic biliary disease
 Absent 159 75.93 7.679 0.962
 Present 13 75.82 5.108  
  1. aMann-Whitney