Table 1 Overview of all reported cases of FOLFOX therapy related pulmonary toxicity
Reference | Patient gender/age (years) | Oncologic diagnosis | Number of FOLFOX cycles | Total dose OX (mg/m2) | Presumed lung disease (Radiology/Laboratory) | Pathology | ILD treatment other than discontinuation of FOLFOX | Artificial Ventilation | Outcome |
|---|---|---|---|---|---|---|---|---|---|
2001 Trisolini Italy | M/60 | Colorectal cancer | 7 | 910 | ILD | BAL: DAD cells TBB: fibroblastic plugs in alveolar spaces, DAD cells | Corticosteroids | No | Complete resolution |
2002 Gagnadoux France | F/60 | Colorectal cancer | 8 | 680 | EP | TBB: no abnormalities | None | No | Complete resolution |
2006 Ruiz-Casado Spain | M/67 | Hepatocellular cancer | NA | 1100 | PF | NA | None | No | Improvement |
2005 Hernandez Yagüe Spain | F/68 | Colorectal cancer | 6 | 510 | PF | LB: IP + DAD | Corticosteroids | Yes | Death |
2006 Jung Korea | M/64 | Gastric cancer | 2 | 200 | PF | TBB: organizing pneumonia | Corticosteroids | No | Improvement |
2006 Jung Korea | M/75 | Gastric cancer | 1 | 100 | ILD | TBB: DAD with hyaline membranes | Corticosteroids | No | Improvement |
2006 Pasetto Italy | M/74 | Colorectal cancer | 6 | 510 | ARDS | TBB: no infection | Corticosteroids | NA | Death |
2007 Garrido Chile | F/30 | Colorectal cancer | 6 | 510 | ILD | LB: COP | Corticosteroids | No | Complete resolution |
2008 Wilcox USA | M/71 | Colorectal cancer | 6 | 600 | ILD | NA | Corticosteroids | Yes | Death |
2008 Wilcox USA | F/77 | Colorectal cancer | 12 | 1200 | IP | NA | None | No | Improvement |
2008 Wilcox USA | M/69 | Colorectal cancer | 6 | NA | ILD | TBB: COP | Acetylcysteine Corticosteroids | No | Improvement |
2007 Mundt Germany | M/66 | Colorectal cancer | 12 | 1020 | Infectious pneumonia | Necropsy: DAD, PF | Corticosteroids | NA | Death |
2009 Muneoka Japan | M/82 | Colorectal cancer | 10 | 850 | IP | NA | Corticosteroids | No | Complete resolution |
2008 Arevalo Lobera Spain | F/73 | Colorectal cancer | 4 | 340 | PF | Necropsy: DAD | Corticosteroids | No | Death |
2008 Arevalo Lobera Spain | M/71 | Colorectal cancer | 4 | 340 | ILD | Necropsy: interstitial inflammatory infiltrate, PF, bilateral bronchopneumonia | Corticosteroids Cyclophosphamide Immune globulins | Yes | Death |
2009 Pena Alvarez Spain | M/62 | Colorectal cancer | 7 | 700 | ILD | NA | Corticosteroids | No (family refused ICU admission) | Death |
2009 Pena Alvarez Spain | M/77 | Colorectal cancer | 7 | 700 | ILD | NA | Corticosteroids | No | Symptomatic resolution |
2012 Hannan Australia | M/74 | Colorectal cancer | 6 | 600 | ILD | Necropsy: DAD | Corticosteroids | No (patient refused intubation) | Death |
2010 Han Lim Korea | M/64 | Gastric cancer | 8 | 680 | ILD/PF | NA | Corticosteroids | Yes | Death |
2013 Shogbon USA | F/78 | Colorectal cancer | 2 | 170 | COP | NA | Corticosteroids | No | Improvement |
2010 Shimura Japan | M/56 | Colorectal cancer | 6 | 510 | ILD | NA | Corticosteroids | NA | Improvement |
2010 Shimura Japan | M/71 | Colorectal cancer | 13 | 1105 | ILD | NA | Corticosteroids | NA | Death |
2010 Shimura Japan | M/73 | Colorectal cancer | 3 | 255 | ILD | NA | Corticosteroids | NA | Improvement |
2010 Shimura Japan | M/76 | Colorectal cancer | 5 | 425 | ILD | NA | Corticosteroids | NA | Improvement |
2010 Shimura Japan | M/73 | Colorectal cancer | 10 | 850 | ILD | NA | Corticosteroids | NA | Death |
2011 Joo Lee Korea | M/57 | Colorectal cancer | 8 | 680 | ILD | LB: organizing pneumonia | Corticosteroids | No | Improvement |
2009 Ohori Japan | M/69 | Colorectal cancer | 11 | 782 | IP | NA | Corticosteroids | Yes | Complete resolution |
2009 Ohori Japan | M/72 | Colorectal cancer | 11 | 935 | IP | NA | Corticosteroids | No | Complete resolution |
2012 Prochilo Italy | M/61 | Gastric cancer | 3 | 255 | IP | NA | Corticosteroids | No | Improvement |
2011 Watkins USA | M/69 | Colorectal cancer | 11 | 795 | EP | Necropsy: DAD | Corticosteroids | Yes | Death |
2011 Ishizone Japan | M/74 | Colorectal cancer | 22 | 1716 | IP | NA | Corticosteroids | Yes | Death |
2014 Cheong Soon UK | F/54 | Colorectal cancer | 12 | 1200 | ILD | NA | Corticosteroids | No | Improvement |
2011 Ryu en Jung Korea | M/55 | Colorectal cancer | 13 | 1105 | IP | NA | Corticosteroids | Yes | Death |
2011 Ryu Jung Korea | M/73 | Colorectal cancer | 8 | 680 | IP | NA | Corticosteroids | Yes | Death |
2011 Homma Japan | M/79 | Colorectal cancer | 12 | 1020 | COP | NA | Corticosteroids | No | Improvement |
2008 Piccolo Australia | M/70 | Colorectal cancer | 11 | 1100 | IP | NA | Corticosteroids Cyclophosphamide | No | Improvement |
2008 Piccolo Australia | M/62 | Colorectal cancer | 12 | 1200 | IP | NA | Corticosteroids | No | Improvement |
2010 Park Korea | M/76 | Colorectal cancer | 10 | 1000 | ILD | NA | None | No | Stable disease |
2014 Basyigit Turkey | M/60 | Colorectal cancer | 6 | 510 | IP | NA | None | No | Improvement |
2009 Dahlqvist Belgium | F/74 | Colorectal cancer | 12 | 1020 | ILD | BAL: alveolitis TBB: BOOP | Corticosteroids | No | Improvement |
2014 Hoon Choi Korea | F/76 | Colorectal cancer | 8 | 800 | Sarcoidosis | NA | Corticosteroids | No | Improvement |
2012 Pontes Brazil | M/75 | Gastric cancer | 9 | 765 | ILD | BAL: no malignant cells | Corticosteroids | Yes | Death |
2012 Pontes Brazil | M/64 | Colorectal cancer | 12 | 1020 | ILD | LB: DAD, inflammatory infiltrate, diffuse thickening of interalveolar septa | Corticosteroids | Yes | Death |
2013 Wildner Germany | M/62 | Colorectal cancer | 1 | 85 | Infectious pneumonia | LB: granulomatous inflammation | Corticosteroids | Yes | Complete resolution |
2015 De Weerdt Belgium | F/49 | Colorectal cancer | 6 | 580 | ILD | LB: IP | Acetylcysteine Corticosteroids Immune globulins Cyclophosphamide | Yes | Complete resolution |