Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non–small-cell lung cancer

Table 2 Longitudinal changes in physical parameters

Variables	Mean difference from baseline (±SE)		Mean difference between T2 and T3 (±SE)
Variables	6 ± 2wks	12 ± 4wks
N	30	28	25
Body weight (kg)	−0.9 ± 0.4*	−1.1 ± 0.6*	−0.2 ± 0.4
Body-mass index (kg/m²)	−0.3 ± 0.1*	−0.4 ± 0.1*	−0.1 ± 0.1
L3 muscle index (cm²/m²)	−1.8 ± 0.4*	−1.8 ± 0.7*	−0.1 ± 0.4
Hand grip strength (non-dominant, kg)	−0.7 ± 0.6	−0.7 ± 0.6	−0.5 ± 0.3
Shuttle walk distance (m)	−40.0 ± 12.6*	−46.4 ± 15.8*	−10.8 ± 11.3
Clinically significant decline^b, n (%)	11 (40.7)	13 (52.0)	5 (20.0)

*p < 0.05 in Wilcoxon signed-rank test compared with baseline value
^bClinically significant decline is defined as losing ≥40 m of shuttle walk distance from baseline

ISSN: 1471-2407