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Table 5 Test characteristics at different faecal haemoglobin concentration by sex and age group

From: Population-based colorectal cancer screening programmes using a faecal immunochemical test: should faecal haemoglobin cut-offs differ by age and sex?

 

Positive predictive valuea [%(95% CI)]

Cut-off μg Hb/g faeces

Women <55 years

Men <55 years

p value

Women 55–60 years

Men 55–60 years

p value

Women 60–65 years

Men 60–65 years

p value

Women >65 years

Men >65 years

p value

20

30.6 (28.5–32.7)

44.0 (42.0–45.9)

< 0.0001

34.2 (32.0–36.4)

51.9 (50.1–53.8)

< 0.0001

32.0 (30.0–34.0)

56.4 (54.7–58.0)

< 0.0001

35.2 (33.0–37.3)

57.4 (55.6–59.2)

< 0.0001

25

34.5 (32.1–36.9)

47.7 (45.5–49.9)

< 0.0001

38.2 (35.6–40.7)

55.2 (50.1–53.8)

< 0.0001

34.6 (32.3–36.9)

59.5 (57.7–61.3)

< 0.0001

38.9 (36.5–41.4)

60.2 (58.2–62.1)

< 0.0001

30

35.7 (33.1–38.3)

49.1 (46.8–51.4)

< 0.0001

40.8 (38.1–43.6)

55.2 (53.1–57.2)

< 0.0001

36.3 (33.8–38.8)

60.4 (58.5–62.3)

< 0.0001

40.2 (37.6–42.8)

61.7 (59.6–63.7)

< 0.0001

35

36.4 (33.7–39.1)

49.9 (47.5–52.2)

< 0.0001

41.6 (38.8–44.5)

56.4 (54.3–58.5)

< 0.0001

37.8 (35.1–40.4)

52.8 (50.8–54.8)

< 0.0001

41.3 (38.5–44.0)

63.3 (61.2–65.4)

< 0.0001

40

38.0 (35.1–40.9)

50.9 (48.4–53.4)

< 0.0001

42.9 (39.8–45.9)

58.0 (55.8–60.2)

< 0.0001

38.8 (36.1–41.6)

62.7 (60.7–64.7)

< 0.0001

42.8 (40.0–45.7)

64.3 (62.1–66.5)

< 0.0001

50

39.9 (36.8–43.0)

52.5 (49.9–55.2)

< 0.0001

43.6 (40.4–46.8)

60.9 (58.5–63.4)

< 0.0001

42.0 (39.0–45.0)

64.2 (62.1–66.3)

< 0.0001

44.4 (41.3–47.5)

66.0 (63.7–68.3)

< 0.0001

60

40.8 (37.5–44.2)

54.2 (51.4–57.0)

< 0.0001

45.1 (41.7–48.6)

62.3 (59.8–64.9)

< 0.0001

42.3 (39.1–45.5)

65.6 (63.4–67.8)

< 0.0001

45.4 (42.1–48.7)

67.3 (64.9–69.7)

< 0.0001

Positivity rate [%(95% CI)]

 20

3.9 (3.8–4.1)

6.1 (5.9–6.3)

< 0.0001

4.4 (4.2–4.6)

7.9 (7.7–8.2)

< 0.0001

5.3 (5.1–5.5)

9.5 (9.2–9.8)

< 0.0001

6.2 (6.0–6.5)

10.7 (10.3–11.0)

< 0.0001

 25

3.1 (3.0–3.3)

5.0 (4.8–5.2)

< 0.0001

3.4 (3.3–3.6)

6.6 (6.4–6.9)

< 0.0001

4.1 (4.0–4.3)

8.1 (7.8–8.3)

< 0.0001

5.0 (4.8–5.3)

9.0 (8.7–9.4)

< 0.0001

 30

2.8 (2.6–2.9)

4.5 (4.3–4.7)

< 0.0001

3.0 (2.8–3.2)

6.0 (5.7–6.2)

< 0.0001

3.6 (3.0–3.4)

7.3 (7.0–7.5)

< 0.0001

4.5 (4.3–4.7)

8.1 (7.8–8.5)

< 0.0001

 35

2.5 (2.4–2.6)

4.1 (3.9–4.3)

< 0.0001

2.7 (2.6–2.9)

5.4 (5.2–5.7)

< 0.0001

3.2 (3.0–3.4)

6.7 (6.5–7.0)

< 0.0001

4.1 (3.8–4.3)

7.5 (7.2–7.8)

< 0.0001

 40

2.3 (2.1–2.4)

3.7 (3.6–3.9)

< 0.0001

2.5 (2.3–2.6)

5.0 (4.8–5.3)

< 0.0001

2.9 (2.8–3.1)

6.2 (6.0–6.5)

< 0.0001

3.7 (3.5–4.0)

6.9 (6.6–7.2)

< 0.0001

 50

2.0 (1.9–2.1)

3.3 (3.1–3.4)

< 0.0001

2.2 (2.1–2.4)

4.4 (4.2–4.6)

< 0.0001

2.5 (2.4–2.7)

5.5 (5.2–5.7)

< 0.0001

3.3 (3.1–3.5)

6.1 (5.8–6.4)

< 0.0001

 60

1.8 (1.6–1.9)

2.9 (2.8–3.1)

< 0.0001

2.0 (1.8–2.1)

3.9 (3.7–4.1)

< 0.0001

2.3 (2.1–2.4)

5.0 (4.8–5.2)

< 0.0001

2.8 (2.7–3.0)

5.5 (5.2–5.8)

< 0.0001

Colorectal Cancer (CRC) Detection Rate [‰ (95% CI)]

 20

1.6 (1.2–2.0)

2.2 (1.7–2.6)

0.053

2.1 (1.7–2.6)

4.5 (3.8–5.2)

< 0.0001

2.3 (1.8–2.7)

6.4 (5.6–7.3)

< 0.0001

3.5 (2.8–4.1)

9.3 (8.1–10.4)

< 0.0001

 25

1.5 (1.2–1.9)

2.0 (1.6–2.4)

0.107

2.0 (1.6–2.4)

4.3 (3.6–5.0)

< 0.0001

2.1 (1.7–2.6)

6.1 (5.3–6.9)

< 0.0001

3.2 (2.6–3.9)

8.7 (7.6–9.8)

< 0.0001

 30

1.5 (1.1–1.8)

1.9 (1.5–2.3)

0.127

2.0 (1.5–2.4)

4.1 (3.4–4.8)

< 0.0001

2.1 (1.6–2.5)

5.9 (5.1–6.7)

< 0.0001

3.0 (2.4–3.6)

8.4 (7.3–9.5)

< 0.0001

 35

1.5 (1.1–1.8)

1.9 (1.5–2.3)

0.127

1.9 (1.5–2.3)

4.0 (3.3–4.7)

< 0.0001

2.0 (1.6–2.5)

5.8 (5.0–6.6)

< 0.0001

2.9 (2.3–3.5)

8.3 (7.2–9.4)

< 0.0001

 40

1.4 (1.1–1.8)

1.8 (1.5–2.3)

0.150

1.8 (1.4–2.2)

3.9 (3.3–4.6)

< 0.0001

2.0 (1.5–2.4)

5.5 (4.8–6.3)

< 0.0001

2.8 (2.2–3.4)

8.0 (7.0–9.1)

< 0.0001

 50

1.4 (1.0–1.7)

1.7 (1.3–2.1)

0.241

1.7 (1.3–2.1)

3.7 (3.1–4.4)

< 0.0001

1.8 (1.4–2.2)

5.3 (4.5–6.0)

< 0.0001

2.6 (2.0–3.2)

7.8 (6.8–8.9)

< 0.0001

 60

1.3 (1.0–1.6)

1.6 (1.2–1.9)

0.328

1.7 (1.3–2.0)

3.6 (3.0–4.2)

< 0.0001

1.7 (1.3–2.1)

5.0 (4.3–5.8)

< 0.0001

2.5 (2.0–3.1)

7.6 (6.5–8.6)

< 0.0001

Advanced Neoplasia (AN) Detection Rate [‰ (95% CI)]

 20

12.1 (11.1–13.0)

26.9 (15.3–28.5)

< 0.0001

15.0 (13.8–16.2)

41.3 (39.2–43.4)

< 0.0001

16.9 (15.6–18.2)

53.6 (51.2–55.9)

< 0.0001

21.9 (20.3–23.6)

61.2 (58.3–64.1)

< 0.0001

 25

10.8 (9.9–11.8)

23.9 (22.5–25.4)

< 0.0001

13.1 (12.0–14.2)

36.5 (34.6–38.5)

< 0.0001

14.4 (13.2–15.5)

47.9 (45.7–50.2)

< 0.0001

19.6 (18.0–21.2)

54.2 (51.5–56.9)

< 0.0001

 30

9.9 (9.0–10.7)

21.9 (20.5–23.3)

< 0.0001

12.3 (11.2–13.3)

33.6 (31.7–35.4)

< 0.0001

13.0 (11.9–14.1)

44.0 (41.9–46.1)

< 0.0001

18.0 (16.5–19.5)

50.1 (47.5–52.8)

< 0.0001

 35

9.1 (8.2–9.9)

20.3 (19.0–21.7)

< 0.0001

11.4 (10.4–12.4)

31.5 (29.6–33.3)

< 0.0001

12.1 (11.1–13.2)

35.6 (33.7–37.5)

< 0.0001

16.8 (15.4–18.2)

47.6 (45.0–50.1)

< 0.0001

 40

8.6 (7.8–9.4)

19.1 (17.8–20.4)

< 0.0001

10.7 (9.7–11.7)

30.0 (28.2–31.8)

< 0.0001

11.4 (10.4–12.4)

39.0 (37.0–47.1)

< 0.0001

16.0 (14.6–17.5)

44.6 (42.1–47.1)

< 0.0001

 50

7.9 (7.1–8.7)

17.2 (15.9–18.4)

< 0.0001

9.7 (8.8–10.7)

26.7 (25.1–28.4)

< 0.0001

10.7 (9.7–11.7)

35.2 (33.3–37.1)

< 0.0001

14.5 (13.1–15.8)

40.4 (38.1–42.8)

< 0.0001

 60

7.2 (6.5–8.0)

16.0 (14.8–17.2)

< 0.0001

8.9 (8.0–9.8)

24.5 (22.9–26.1)

< 0.0001

9.7 (8.7–10.7)

32.8 (30.9–34.7)

< 0.0001

12.9 (11.7–14.2)

37.1 (34.9–39.4)

< 0.0001

  1. aPPV applies for AN: defined as advanced adenoma (AA) plus colorectal cancer (CRC). Advanced adenomas: adenomas ≥10 mm, ≥3 adenoma, adenoma with a villous component (i.e., tubulovillous or villous adenoma) or adenomas with severe/high-grade dysplasia
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