Table 4 Test characteristics at different faecal haemoglobin concentration cut-offs by sex
Positive predictive valuea (%) | Positivity rate (%) | Colorectal cancer detection rate (‰) | Advanced neoplasia detection rate (‰) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cut-off μg Hb/g faeces | Men | Women | p value | Men | Women | p value | Men | Women | p value | Men | Women | p value |
20 | 52.8 (51.9–53.7) | 32.9 (31.9–34.0) | < 0.0001 | 8.3 (8.1–8.4) | 4.8 (4.7–4.9) | < 0.0001 | 5.2 (4.8–5.6) | 2.2 (2.0–2.4) | < 0.0001 | 44.0 (42.9–45.1) | 15.9 (15.2–16.5) | < 0.0001 |
25 | 56.0 (55.0–57.0) | 36.5 (35.2–37.7) | < 0.0001 | 6.9 (6.8–7.1) | 3.8 (3.7–3.9) | < 0.0001 | 4.9 (4.5–5.3) | 2.1 (1.9–2.3) | < 0.0001 | 39.0 (38.0–40.1) | 13.9 (13.3–14.5) | < 0.0001 |
30 | 57.4 (56.3–58.4) | 38.3 (37.0–39.6) | < 0.0001 | 6.2 (6.1–6.4) | 3.3 (3.2–3.4) | < 0.0001 | 4.7 (4.3–5.1) | 2.0 (1.8–2.2) | < 0.0001 | 36.0 (35.0–37.0) | 12.8 (12.3–13.4) | < 0.0001 |
35 | 58.6 (57.5–59.7) | 39.2 (37.8–40.5) | < 0.0001 | 5.7 (5.6–5.8) | 3.0 (2.9–3.1) | < 0.0001 | 4.6 (4.3–5.0) | 1.9 (1.7–2.2) | < 0.0001 | 33.8 (32.8–34.7) | 11.9 (11.3–12.4) | < 0.0001 |
40 | 59.8 (58.7–61.0) | 40.6 (39.1–42.0) | < 0.0001 | 5.3 (5.2–5.4) | 2.7 (2.6–2.8) | < 0.0001 | 4.5 (4.1–4.8) | 1.9 (1.6–2.1) | < 0.0001 | 31.9 (31.0–32.8) | 11.2 (10.7–11.7) | < 0.0001 |
50 | 61.5 (60.3–62.6) | 42.2 (40.6–43.7) | < 0.0001 | 4.6 (4.5–4.7) | 2.4 (2.3–2.5) | < 0.0001 | 4.3 (3.9–4.6) | 1.7 (1.5–2.0) | < 0.0001 | 28.7 (27.8–29.6) | 10.2 (9.7–10.7) | < 0.0001 |
60 | 62.7 (61.5–64.0) | 43.3 (41.7–45.0) | < 0.0001 | 4.2 (4.1–4.3) | 2.1 (2.0–2.2) | < 0.0001 | 4.1 (3.8–4.4) | 1.7 (1.5–1.9) | < 0.0001 | 26.5 (25.7–27.4) | 9.3 (8.8–9.8) | < 0.0001 |