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Table 4 Test characteristics at different faecal haemoglobin concentration cut-offs by sex

From: Population-based colorectal cancer screening programmes using a faecal immunochemical test: should faecal haemoglobin cut-offs differ by age and sex?

  Positive predictive valuea (%) Positivity rate (%) Colorectal cancer detection rate (‰) Advanced neoplasia detection rate (‰)
Cut-off μg Hb/g faeces Men Women p value Men Women p value Men Women p value Men Women p value
20 52.8 (51.9–53.7) 32.9 (31.9–34.0) < 0.0001 8.3 (8.1–8.4) 4.8 (4.7–4.9) < 0.0001 5.2 (4.8–5.6) 2.2 (2.0–2.4) < 0.0001 44.0 (42.9–45.1) 15.9 (15.2–16.5) < 0.0001
25 56.0 (55.0–57.0) 36.5 (35.2–37.7) < 0.0001 6.9 (6.8–7.1) 3.8 (3.7–3.9) < 0.0001 4.9 (4.5–5.3) 2.1 (1.9–2.3) < 0.0001 39.0 (38.0–40.1) 13.9 (13.3–14.5) < 0.0001
30 57.4 (56.3–58.4) 38.3 (37.0–39.6) < 0.0001 6.2 (6.1–6.4) 3.3 (3.2–3.4) < 0.0001 4.7 (4.3–5.1) 2.0 (1.8–2.2) < 0.0001 36.0 (35.0–37.0) 12.8 (12.3–13.4) < 0.0001
35 58.6 (57.5–59.7) 39.2 (37.8–40.5) < 0.0001 5.7 (5.6–5.8) 3.0 (2.9–3.1) < 0.0001 4.6 (4.3–5.0) 1.9 (1.7–2.2) < 0.0001 33.8 (32.8–34.7) 11.9 (11.3–12.4) < 0.0001
40 59.8 (58.7–61.0) 40.6 (39.1–42.0) < 0.0001 5.3 (5.2–5.4) 2.7 (2.6–2.8) < 0.0001 4.5 (4.1–4.8) 1.9 (1.6–2.1) < 0.0001 31.9 (31.0–32.8) 11.2 (10.7–11.7) < 0.0001
50 61.5 (60.3–62.6) 42.2 (40.6–43.7) < 0.0001 4.6 (4.5–4.7) 2.4 (2.3–2.5) < 0.0001 4.3 (3.9–4.6) 1.7 (1.5–2.0) < 0.0001 28.7 (27.8–29.6) 10.2 (9.7–10.7) < 0.0001
60 62.7 (61.5–64.0) 43.3 (41.7–45.0) < 0.0001 4.2 (4.1–4.3) 2.1 (2.0–2.2) < 0.0001 4.1 (3.8–4.4) 1.7 (1.5–1.9) < 0.0001 26.5 (25.7–27.4) 9.3 (8.8–9.8) < 0.0001
  1. aPPV applies for AN: defined as advanced adenoma (AA) plus colorectal cancer (CRC). Advanced adenomas: adenomas ≥10 mm, ≥3 adenoma, adenoma with a villous component (i.e., tubulovillous or villous adenoma) or adenomas with severe/high-grade dysplasia