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Table 2 Univariate and multivariate analyses of the factors that are predictive of overall survival in all patients (n = 158)

From: Prognostic impact of a new score using neutrophil-to-lymphocyte ratios in the serum and malignant pleural effusion in lung cancer patients

Variable Univariate analysis Multivariate analysis
MST, mo 95% CI P value HR 95% CI P value
Age, years    <0.001    
  < 65
  ≥ 65
13.6
4.3
11.1–16.2
2.7–5.9
    
Sex    0.103    
 Male
 Female
5.0
9.5
2.8–7.3
6.5–12.5
    
Smoking habit    0.052    
 Current + Former
 Never
4.5
9.7
2.1–6.9
6.8–12.6
    
ECOG PS    <0.001    <0.001
 0–1
 2–4
13.6
2.4
11.8–15.4
1.5–3.3
  reference
3.88
2.66–5.64  
Histology    <0.001    0.001
 ADC
 SQC
 Others
 SCC
8.5
3.7
1.5
3.1
5.7–11.3
0.0–11.0
0.0–4.2
0.8–5.4
  reference
2.07
4.79
2.25
1.01–4.26
1.86–12.36
1.09–4.65
0.048
0.001
0.029
M Stage    0.002    
 M1a
 M1b
10.9
4.3
6.9–14.9
2.6–6.0
    
Treatment    0.007    
 Supportive
 Active
3.2
10.9
1.9–4.5
8.1–13.7
    
Hemoglobin, g/dLa    0.004    
  < 12
  ≥ 12
3.3
9.2
0.7–5.9
6.5–12.0
    
Albumin, g/dLa    <0.001    
  < 3.1
  ≥ 3.1
2.6
9.5
1.1–4.0
6.7–12.3
    
LDH, IU/La    0.119    
  ≤ 211
  > 211
10.6
4.5
8.1–13.1
3.1–6.0
    
Calcium, mg/dLa    <0.001    
  ≤ 10.8
  > 10.8
7.7
1.0
5.1–10.2     
sNLR    <0.001    
  < 3.85
  ≥ 3.85
12.6
3.6
9.7–15.6
2.2–5.0
    
mNLR    0.004    
  < 1.36
  ≥ 1.36
8.3
2.4
5.1–11.4
0.5–4.3
    
smNLR score    <0.001    0.012
 0
 1
 2
12.6
4.4
1.6
9.7–15.6
2.7–6.0
1.4–1.8
  reference
1.37
2.36
0.95–1.98
1.30–4.28
0.090
0.005
  1. Abbreviations: MST median survival time, mo month, CI confidence interval, HR hazard ratio, ECOG PS Eastern Cooperative Oncology Group performance status, ADC adenocarcinoma, SQC squamous cell carcinoma, SCC small cell carcinoma, sNLR neutrophil-to-lymphocyte ratio of serum, mNLR neutrophil-to-lymphocyte ratio of malignant pleural effusion, smNLR score score using neutrophil-to-lymphocyte ratios of serum and malignant pleural effusion
  2. aDichotomized by cutoff of normal value