Table 2 Univariate and multivariate analyses of the factors that are predictive of overall survival in all patients (n = 158)

Age, years

  < 65

  ≥ 65

13.6

4.3

11.1–16.2

2.7–5.9

Sex

 Male

 Female

5.0

9.5

2.8–7.3

6.5–12.5

Smoking habit

 Current + Former

 Never

4.5

9.7

2.1–6.9

6.8–12.6

ECOG PS

<0.001

 0–1

 2–4

13.6

2.4

11.8–15.4

1.5–3.3

reference

3.88

2.66–5.64

Histology

0.001

 ADC

 SQC

 Others

 SCC

8.5

3.7

1.5

3.1

5.7–11.3

0.0–11.0

0.0–4.2

0.8–5.4

reference

2.07

4.79

2.25

1.01–4.26

1.86–12.36

1.09–4.65

0.048

0.001

0.029

M Stage

 M1a

 M1b

10.9

4.3

6.9–14.9

2.6–6.0

Treatment

 Supportive

 Active

3.2

10.9

1.9–4.5

8.1–13.7

Hemoglobin, g/dL^a

  < 12

  ≥ 12

3.3

9.2

0.7–5.9

6.5–12.0

Albumin, g/dL^a

  < 3.1

  ≥ 3.1

2.6

9.5

1.1–4.0

6.7–12.3

LDH, IU/L^a

  ≤ 211

  > 211

10.6

4.5

8.1–13.1

3.1–6.0

Calcium, mg/dL^a

  ≤ 10.8

  > 10.8

7.7

1.0

5.1–10.2

sNLR

  < 3.85

  ≥ 3.85

12.6

3.6

9.7–15.6

2.2–5.0

mNLR

  < 1.36

  ≥ 1.36

8.3

2.4

5.1–11.4

0.5–4.3

smNLR score

0.012

 0

 1

 2

12.6

4.4

1.6

9.7–15.6

2.7–6.0

1.4–1.8

reference

1.37

2.36

0.95–1.98

1.30–4.28

0.090

0.005